{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:07:40Z","timestamp":1791644860829,"version":"4.3.4"},"reference-count":140,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Women with polycystic ovary syndrome (PCOS) exhibit reduced muscle insulin\u2010mediated glucose uptake, potentially attributed to altered muscle mass; however, this is inconclusive. Altered muscle mass may aggravate PCOS complications. Our systematic review and meta\u2010analysis evaluated whether PCOS alters muscle mass and function. Databases (MEDLINE, Web of Science, Scopus) were searched through September 2, 2020, for studies documenting skeletal muscle mass (lean tissue mass) and function (strength) in PCOS and control groups. The primary outcome was total lean body mass (LBM) or fat\u2010free mass (FFM). Data were pooled by random\u2010effects models and expressed as mean differences and 95% confidence intervals. Forty\u2010five studies (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u20093676 participants) were eligible. Women with PCOS had increased total (0.83 [0.08,1.58]\u00a0kg;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.03;\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u200972.0%) yet comparable trunk (0.84 [\u22120.37,2.05]\u00a0kg;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.15;\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u200973.0%) LBM or FFM versus controls. Results of meta\u2010regression analyses showed no associations between mean differences between groups in total testosterone or homeostatic model assessment of insulin resistance and total or trunk LBM or FFM (All:\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0\u2265\u20090.75). Mean differences in body mass index (BMI) were associated with total (0.65 [0.23,1.06]\u00a0kg;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u20090.01;\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u200956.9%) and trunk (0.56 [0.11,1.01]\u00a0kg;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.02;\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u200942.8%) LBM or FFM. The PCOS subgroup with BMI\u2009\u2265\u200925\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    had greater total LBM or FFM versus controls (1.58 [0.82,2.34]\u00a0kg;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u20090.01;\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u200964.0%) unlike the PCOS subgroup with BMI\u2009&lt;\u200925\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    (\u22120.45 [\u22121.94,1.05]\u00a0kg;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.53;\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u200969.5%). Appendicular lean mass and muscle strength data were contradictory and described narratively, as meta\u2010analyses were impossible. Women with PCOS have higher total and trunk lean tissue mass attributed to overweight\/obesity, unlike hyperandrogenism or insulin resistance.\n                  <\/jats:p>","DOI":"10.1111\/obr.13255","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T17:20:22Z","timestamp":1618507222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Obesity, but not hyperandrogenism or insulin resistance, predicts skeletal muscle mass in reproductive\u2010aged women with polycystic ovary syndrome: A systematic review and meta\u2010analysis of 45 observational studies"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6001-7208","authenticated-orcid":false,"given":"Maryam","family":"Kazemi","sequence":"first","affiliation":[{"name":"Division of Nutritional Sciences, Human Metabolic Research Unit Cornell University  Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4435-0515","authenticated-orcid":false,"given":"Roger A.","family":"Pierson","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, College of Medicine University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Parry","sequence":"additional","affiliation":[{"name":"Cornell Statistical Consulting Unit Cornell University  Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1186-3384","authenticated-orcid":false,"given":"Mojtaba","family":"Kaviani","sequence":"additional","affiliation":[{"name":"School of Nutrition and Dietetics Acadia University  Wolfville Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3973-5939","authenticated-orcid":false,"given":"Philip D.","family":"Chilibeck","sequence":"additional","affiliation":[{"name":"College of Kinesiology, Physical Activity Complex University of Saskatchewan  Saskatoon Saskatchewan 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