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The purpose of this study was to review the current strategies for iron supplementation following bariatric surgery and assess their relative efficacy in managing ID and IDA. MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials were searched to January 2021. Primary outcomes of interest were prevention or improvement in ID or IDA with iron supplementation. Forty\u2010nine studies with 12,880 patients were included. Most patients underwent Roux\u2010en\u2010Y gastric bypass (61.9%). Iron supplementation was most commonly administered orally for prevention of ID\/IDA and was effective in 52% of studies. Both IV and oral iron were given for treatment of ID\/IDA. Fifty percent (3\/6) of the oral and 100% (3\/3) of the IV supplementation strategies were effective at treating ID. Iron supplementation strategies employed following bariatric surgery are highly variable, and many do not provide sufficient iron to prevent the development of ID and IDA, potentially due to poor patient adherence. Further high\u2010quality prospective trials, particularly comparing intravenous and oral iron, are warranted in order to determine the ideal dosage, route, and duration of iron supplementation.<\/jats:p>","DOI":"10.1111\/obr.13268","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T02:02:21Z","timestamp":1621476141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Iron supplementation following bariatric surgery: A systematic review of current strategies"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7284-8735","authenticated-orcid":false,"given":"Sama","family":"Anvari","sequence":"first","affiliation":[{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Faculty of Health Sciences McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasith","family":"Samarasinghe","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouf","family":"Alotaiby","sequence":"additional","affiliation":[{"name":"Division of General Surgery McMaster University  Hamilton Ontario Canada"},{"name":"Centre for Minimal Access Surgery (CMAS), St. Joseph's Healthcare McMaster University  Hamilton Ontario Canada"},{"name":"Department of General Surgery, King Abdulaziz University Hospital King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tiboni","sequence":"additional","affiliation":[{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Crowther","sequence":"additional","affiliation":[{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Department of Pathology and Molecular Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0543-3177","authenticated-orcid":false,"given":"Aristithes G.","family":"Doumouras","sequence":"additional","affiliation":[{"name":"Division of General Surgery McMaster University  Hamilton Ontario Canada"},{"name":"Centre for Minimal Access Surgery (CMAS), St. Joseph's Healthcare McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24820"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831\/a000033"},{"issue":"8","key":"e_1_2_10_4_1","article-title":"Surgery for weight loss in adults","volume":"8","author":"Colquitt JL","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2013.10.023"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01421.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001880"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2010.10.013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2013.12.004"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16409"},{"issue":"10","key":"e_1_2_10_11_1","first-page":"946","article-title":"Burden of iron deficiency anemia in a bariatric surgery population in the United States","volume":"21","author":"Knight T","year":"2015","journal-title":"J Manag Care Pharm"},{"issue":"6","key":"e_1_2_10_12_1","first-page":"640","article-title":"Iron deficiency and anaemia in bariatric surgical patients: causes, diagnosis and proper management","volume":"24","author":"Mu\u00f1oz M","year":"2009","journal-title":"Nutr Hosp"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2013.01.019"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13773"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2019.10.025"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-013-0939-6"},{"issue":"3","key":"e_1_2_10_17_1","first-page":"e123","article-title":"Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses: the PRISMA statement","volume":"3","author":"Moher D","year":"2009","journal-title":"Open Med"},{"key":"e_1_2_10_18_1","first-page":"1","article-title":"Synthesis Without Meta\u2010analysis (SWiM) in systematic reviews: reporting guideline","volume":"368","author":"Campbell M","year":"2020","journal-title":"BMJ"},{"key":"e_1_2_10_19_1","unstructured":"CDC.Iron Status. 2017\u20102018 Data Documentation Codebook and Frequencies 2020. 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