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A comprehensive search was conducted in electronic databases, up to November 2020. Eleven cross\u2010sectional studies that reported the link between circulating vitamin D levels and MetS in children were included in the analysis. Combining 11 effect sizes from 11 cross\u2010sectional studies with 22,196 participants revealed that highest versus lowest serum vitamin D concentration was significantly associated with a 50% reduced odds of MetS in children (OR: 0.50; 95%CI: 0.39, 0.64). Subgroup analysis by study location revealed decreased odds of MetS in both non\u2010Asian (OR: 0.45; 95%CI: 0.33, 0.63) and Asian countries (OR: 0.54; 95%CI: 0.39, 0.76) with no heterogeneity in these subgroups. When we confined the studies to those with representative populations (<jats:italic>n<\/jats:italic>\u00a0=\u200921,611), a significant inverse association was found between highest versus lowest circulating vitamin D level and MetS (OR: 0.55; 95%CI: 0.42, 0.71). Dose\u2013response analysis showed that each 10\u2009ng\/ml (or 25\u2009nmol\/L) in serum vitamin D was linearly related to a 12% reduced odds of MetS (OR: 0.88; 95%CI: 0.78, 0.99) in children. A nonlinear association was also detected between serum 25(OH)D and MetS. This meta\u2010analysis revealed that circulating vitamin D concentration was inversely associated with odds of MetS in children, in a dose\u2013response fashion. The same finding was found in the studies with representative populations.<\/jats:p>","DOI":"10.1111\/obr.13314","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T06:15:48Z","timestamp":1625638548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Circulating serum vitamin D levels in relation to metabolic syndrome in children: A systematic review and dose\u2013response meta\u2010analysis of epidemiologic studies"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0141-0998","authenticated-orcid":false,"given":"Parisa","family":"Rouhani","sequence":"first","affiliation":[{"name":"Students' Research Committee Isfahan University of Medical Sciences  Isfahan Iran"},{"name":"Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center Isfahan University of Medical Sciences  Isfahan 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