{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T21:02:56Z","timestamp":1793480576277,"version":"4.5.0"},"reference-count":82,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012866","name":"Cumming School of Medicine, University of Calgary","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012866","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Excess body fat is a major risk factor for endometrial cancer incidence, but its impact on recurrence and survival remains unclear. The aim of this systematic review and meta\u2010analysis was to assess the association between excess body fat with recurrence, cancer\u2010specific, and all\u2010cause mortality among endometrial cancer survivors. We searched MEDLINE and EMBASE databases up to July 2021. Risk of bias was assessed with the Ottawa Newcastle Scale. Random effects models estimated pooled hazard ratios for the main associations between body mass index (BMI) and survival outcomes and stratified by endometrial cancer type. Potential heterogeneity and publication bias were evaluated with sensitivity analyses, funnel plots, and Egger's test. Forty\u2010six studies were included, of which 45 estimated body fat with BMI and six used direct waist circumference measures or CT\/MRI scans. Higher BMI (\u226530\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) was associated with increased all\u2010cause mortality (HR\u2009=\u20091.34, 95%CI\u2009=\u20091.12\u20131.59) and recurrence (HR\u2009=\u20091.28, 95%CI\u2009=\u20091.06\u20131.56). In sub\u2010group analysis, associations between higher BMI and all\u2010cause mortality were observed for both Types I and II survivors, while recurrence associations were only significant among Type I cases. Obesity at endometrial cancer diagnosis was associated with increased cancer recurrence and all\u2010cause mortality among endometrial cancer survivors but not endometrial cancer\u2010specific mortality.\n                  <\/jats:p>","DOI":"10.1111\/obr.13337","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T02:21:29Z","timestamp":1630635689000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Obesity and mortality among endometrial cancer survivors: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1723-8421","authenticated-orcid":false,"given":"Ren\u00e9e L.","family":"Kokts\u2010Porietis","sequence":"first","affiliation":[{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary Calgary Alberta Canada"},{"name":"Department of Cancer Epidemiology and Prevention Research, Cancer Care Alberta Alberta Health Services Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seham","family":"Elmrayed","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3027-290X","authenticated-orcid":false,"given":"Darren R.","family":"Brenner","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary Calgary Alberta Canada"},{"name":"Department of Cancer Epidemiology and Prevention Research, Cancer Care Alberta Alberta Health Services Calgary Alberta Canada"},{"name":"Department of Oncology, Cumming School of Medicine University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4783-1966","authenticated-orcid":false,"given":"Christine M.","family":"Friedenreich","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary Calgary Alberta Canada"},{"name":"Department of Cancer Epidemiology and Prevention Research, Cancer Care Alberta Alberta Health Services Calgary Alberta Canada"},{"name":"Department of Oncology, Cumming School of Medicine University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.11.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_9_4_1","unstructured":"WCRF\/AICR.Continuous Update Project Expert Report 2018 Diet nutrition physical activity and endometrial cancer. Available atdietandcancerreport.org. 2018;"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1606602"},{"key":"e_1_2_9_6_1","unstructured":"Canadian Cancer Statistics Advisory Committee.Canadian Cancer Statistics.2019;"},{"key":"e_1_2_9_7_1","unstructured":"World Health Organization.Obesity: preventing and managing the global epidemic. Report of a WHO consultation. WHO Technical Report Series No 894. Geneva World Health Organization 2000."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30084-1"},{"issue":"2","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1515\/hmbci-2015-0022","article-title":"A weighty problem: metabolic perturbations and the obesity\u2010cancer link","volume":"23","author":"O'Flanagan CH","year":"2015","journal-title":"Horm Mol Biol Clin Investig"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2019.02.002"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.10.020"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2431-2"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2012.12.003"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.03.001"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000874"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.06.023"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.04.006"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.09.088"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.01.032"},{"issue":"11","key":"e_1_2_9_21_1","first-page":"1814","article-title":"Body mass index as a prognostic factor in endometrioid adenocarcinoma of the endometrium","volume":"98","author":"Gates EJ","year":"2006","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.46"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9152-7"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000236047.42283.b8"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e318277d5f4"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.03.258"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22351"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000970"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.10.029"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.00790.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq006"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021423"},{"issue":"2","key":"e_1_2_9_33_1","first-page":"260","article-title":"Risk of endometrial cancer mortality by ever\u2010use of sex hormones and other factors in Japan","volume":"7","author":"Khan M","year":"2006","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2005.08.002"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39367.495995.AE"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.06.036"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.5596\/c14-016"},{"key":"e_1_2_9_38_1","unstructured":"World Health Organization.International classification of diseases for oncology.2013."},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2012.031"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12612"},{"key":"e_1_2_9_41_1","volume-title":"D OC. The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analyses","author":"Gsb W","year":"2014"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.48.2596"},{"key":"e_1_2_9_43_1","volume-title":"Stata Statistical Software: Release 15","author":"StataCorp","year":"2017"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21917"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24667"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-019-05414-3"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.10.003"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13020"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.12.025"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000642"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14560"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.11.050"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjod.galenos.2020.83773"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2020.10.005"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14442"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0242733"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171250"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2019.11.004"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.01.020"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.08.022"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.2217\/14796694.4.6.857"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.11.020"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.11.032"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5237-9"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.10.045"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2019.100502"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2020.06.488"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.04.036"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyu106"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17165941"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyaa274"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.13108"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-019-05281-y"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30288-2"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs530"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30931"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-016-0813-7"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5770-6"},{"key":"e_1_2_9_79_1","volume-title":"Cancer Epidemiology and Prevention","author":"Schottenfeld D","year":"2018"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.230"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn397"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.02.023"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.08.022"}],"container-title":["Obesity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/obr.13337","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/obr.13337","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/obr.13337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T02:30:14Z","timestamp":1699410614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/obr.13337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,2]]},"references-count":82,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/obr.13337"],"URL":"https:\/\/doi.org\/10.1111\/obr.13337","archive":["Portico"],"relation":{},"ISSN":["1467-7881","1467-789X"],"issn-type":[{"value":"1467-7881","type":"print"},{"value":"1467-789X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,2]]},"assertion":[{"value":"2021-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13337"}}