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Skewed cellular metabolism shapes immune cell inflammatory responsiveness and function in obesity, T2D, and infection. However, altered immune cell responsiveness and levels of systemic proinflammatory mediators, partly independent of peripheral immune cell contribution, are linked with SARS\u2010CoV\u20102\u2010associated disease severity. Despite such knowledge, the role of tissue parenchymal cell\u2010driven inflammatory responses, and specifically those dominantly modified in obesity (e.g., adipocytes), in influenza and SARS\u2010CoV\u20102 infection pathogenesis remain poorly defined. Whether obesity\u2010dependent skewing of adipocyte cellular metabolism uncovers inflammatory clades and promotes the existence of a \u2018pathogenic\u2010inflammatory\u2019 adipocyte phenotype that amplifies SARS\u2010CoV\u20102 infection diseases severity in individuals with obesity and individuals with obesity and T2D has not been examined. Here, using the knowledge gained from studies of immune cell responses in obesity, T2D, and infection, we highlight the key knowledge gaps underlying adipocyte cellular functions that may sculpt and grease pathogenic processes associated with influenza and SARS\u2010CoV\u20102 disease severity in diabetes.<\/jats:p>","DOI":"10.1111\/obr.13415","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T04:34:24Z","timestamp":1641443664000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Greasing the inflammatory pathogenesis of viral pneumonias in diabetes"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4617-2564","authenticated-orcid":false,"given":"Michelle S. M. 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