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ORG is associated with serious health consequences including chronic kidney disease, end\u2010stage renal disease (ESRD), and increased mortality. Although the pathogenic mechanisms involved in the development of ORG are not fully understood, glomerular hemodynamic changes, renin\u2010angiotensin\u2010aldosterone system (RAAS) overactivation, insulin\u2010resistance, inflammation and ectopic lipid accumulation seem to play a major role. Despite albuminuria being commonly used for the non\u2010invasive evaluation of ORG, promising biomarkers of early kidney injury that are emerging, as well as new approaches with proteomics and metabolomics, might permit an earlier diagnosis of this disease. In addition, the assessment of ectopic kidney fat by renal imaging could be a useful tool to detect and evaluate the progression of ORG. Weight loss interventions appear to be effective in ORG, although large\u2010scale trials are needed. RAAS blockade has a renoprotective effect in patients with ORG, but even so, a significant proportion of patients with ORG will eventually progress to ESRD despite therapeutic efforts. It is noteworthy that certain antidiabetic agents such as sodium\u2010glucose cotransporter 2 inhibitors (SGLT2i) or glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) could be useful in the treatment of ORG through different pleiotropic effects. In this article, we review current approaches and future perspectives in the care and treatment of ORG.<\/jats:p>","DOI":"10.1111\/obr.13450","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T09:12:25Z","timestamp":1648804345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Obesity\u2010related glomerulopathy: Current approaches and future perspectives"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9761-6888","authenticated-orcid":false,"given":"Jos\u00e9 Ignacio","family":"Mart\u00ednez\u2010Montoro","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Nutrition Virgen de la Victoria University Hospital  M\u00e1laga Spain"},{"name":"Faculty of Medicine University of M\u00e1laga  M\u00e1laga Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga\u2013IBIMA  M\u00e1laga 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