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Adenosine is a critical extracellular signaling molecule that has essential functions in regulating most organ systems by binding to four G\u2010protein\u2010coupled adenosine receptors, denoted A<jats:sub>1<\/jats:sub>, A<jats:sub>2A<\/jats:sub>, A<jats:sub>2B<\/jats:sub>, and A<jats:sub>3<\/jats:sub>. Among the receptors, a growing body evidence highlights the key roles of the adenosine 2A receptor (A<jats:sub>2A<\/jats:sub>R) in obesity and related diseases. In the current review, we summarize the effects of A<jats:sub>2A<\/jats:sub>R in obesity and obesity\u2010associated non\u2010alcoholic fatty liver disease, diabetes, atherosclerosis, and osteoarthritis, to clarify the complicated impacts of A<jats:sub>2A<\/jats:sub>R on obesity and related diseases.<\/jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/obr13490-toc-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1111\/obr.13490","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T13:04:58Z","timestamp":1657199098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pathophysiology roles for adenosine 2A receptor in obesity and related 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