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However, efficacy and safety of obesity medications vary for individuals. Early identification of non\u2010responders to obesity medications may limit drug exposure while optimizing benefits for responders. This review summarizes factors that impact weight\u2010loss response to liraglutide. Factors linked to greater weight loss on liraglutide include being female, not having diabetes, having relatively high baseline weight, and losing at least 4% of initial weight after 16\u2009weeks of treatment. Other covariates that may predict treatment response but require further confirmation include central effects, nausea, gastric emptying of solids, and genotype. Baseline body mass index, race, and age seem less relevant for predicting weight\u2010loss response to liraglutide. Lesser known and harder\u2010to\u2010measure factors such as cerebral blood flow, food cue reactivity, gut hormone levels, and dietary adherence possibly impact variability of response to liraglutide. 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Importantly, this review may provide a framework to identify responders to other obesity medications.<\/jats:p>","DOI":"10.1111\/obr.13568","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T22:54:32Z","timestamp":1681772072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Potential contributors to variation in weight\u2010loss response to liraglutide"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7884-1326","authenticated-orcid":false,"given":"Chelsi M.","family":"Webster","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences Texas Tech University  Lubbock Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Texas Tech University Health Sciences Center  Lubbock Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Dhurandhar","sequence":"additional","affiliation":[{"name":"Obthera, Inc  Lubbock Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil V.","family":"Dhurandhar","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences Texas Tech University  Lubbock Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008\u20101057"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105816"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607111415110"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012908"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003\u2010031438"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004\u20102081"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281361"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.7602"},{"key":"e_1_2_9_10_1","unstructured":"Qsiva. 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