{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:17:35Z","timestamp":1793661455090,"version":"4.5.1"},"reference-count":74,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glucagon\u2010like peptide 1 (GLP\u20101) analogs regulate body weight and liver steatosis. Different body adipose tissue (AT) depots exhibit biological variability. Accordingly, GLP\u20101 analog effects on AT distribution are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate GLP1\u2010analog effects on adiposity distribution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Search methods<\/jats:title>\n                    <jats:p>PubMed, Cochrane, and Scopus databases were screened for eligible randomized human trials. Pre\u2010defined endpoints included visceral AT (VAT), subcutaneous AT (SAT), total AT (TAT), epicardial AT (EAT), liver AT (LAT), and waist\u2010to\u2010hip ratio (W:H). Search was conducted until May 17, 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data collection and analysis<\/jats:title>\n                    <jats:p>Data extraction and bias assessment were performed by two independent investigators. Treatment effects were estimated using random effects models. Analyses were performed on Review Manager v5.3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main results<\/jats:title>\n                    <jats:p>Out of the 367 screened studies, 45 were included in the systematic review and 35 were used in the meta\u2010analysis. GLP\u20101 analogs reduced VAT, SAT, TAT, LAT, and EAT, with non\u2010significant effects on W:H. Overall bias risk was low.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20101 analog treatment reduces TAT, affecting most studied AT depots, including the pathogenic VAT, EAT, and LAT. GLP\u20101 analogs may have significant roles in combating metabolic, obesity\u2010associated diseases via reductions of key AT depot volumes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/obr.13574","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T07:09:38Z","timestamp":1684220978000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["GLP\u20101 analogs and regional adiposity: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"24","author":[{"given":"Ioannis","family":"Akoumianakis","sequence":"first","affiliation":[{"name":"Metabolic Diseases Research Unit, Internal Medicine Laboratory, Department of Internal Medicine, School of Medicine University of Crete  Heraklion Greece"},{"name":"Internal Medicine Clinic University Hospital of Heraklion  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Zagaliotis","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Research Unit, Internal Medicine Laboratory, Department of Internal Medicine, School of Medicine University of Crete  Heraklion Greece"},{"name":"Internal Medicine Clinic University Hospital of Heraklion  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Konstantaraki","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Research Unit, Internal Medicine Laboratory, Department of Internal Medicine, School of Medicine University of Crete  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1713-0923","authenticated-orcid":false,"given":"Theodosios D.","family":"Filippatos","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Research Unit, Internal Medicine Laboratory, Department of Internal Medicine, School of Medicine University of Crete  Heraklion Greece"},{"name":"Internal Medicine Clinic University Hospital of Heraklion  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvx111"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/38447238"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010021\u201006824\u20107"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154770"},{"key":"e_1_2_10_6_1","volume-title":"LiverTox: clinical and research information on drug\u2010induced liver injury","year":"2012"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300\u2010020\u201000816\u2010y"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603827"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav8824"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2478\/rjim\u20102019\u20100003"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/HMER.S265631"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154\u2010014\u20109289\u20105"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010016\u20100384\u20104"},{"key":"e_1_2_10_15_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions version 6.2","author":"Higgins JPT","year":"2021"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12836"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20101326.2009.01158.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2016.1251892"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12932"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13037"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.03.017"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13697"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2028395"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13575"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14464"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16608"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(09)61375\u20101"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.158"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13167"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ16\u20100449"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21718"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14078"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20\u20102151"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14224"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.3224"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12464"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010019\u201005021\u20106"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2020.107548"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14090"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz140"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010020\u201005265\u20107"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9103213"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12624"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/osp4.324"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13487"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010019\u20100890\u20105"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2018.08.010"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13063"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13053"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12795"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.1220"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.08.038"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(15)00803\u2010X"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12680"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010016\u20104100\u20107"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2015.03.005"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE\u201013\u20100797"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11\u20100931"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.152"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.8.1915"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944\u2010018\u20100856\u20108"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.015000"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010018\u20100734\u20108"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010019\u20100917\u2010y"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu045"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v9.i16.715"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(14)70032\u20104"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392\u2010020\u201001709\u20107"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7064995"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.85.3.253"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201020450\u2010w"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.175315"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0004\u20102803.202000000\u201027"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524020666201201095029"}],"container-title":["Obesity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/obr.13574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T11:00:32Z","timestamp":1692270032000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/obr.13574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":74,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/obr.13574"],"URL":"https:\/\/doi.org\/10.1111\/obr.13574","archive":["Portico"],"relation":{},"ISSN":["1467-7881","1467-789X"],"issn-type":[{"value":"1467-7881","type":"print"},{"value":"1467-789X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,16]]},"assertion":[{"value":"2022-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13574"}}