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M<jats:sup>6<\/jats:sup>A methylation enables transcriptome conversion in different signals that regulate various physiological activities and organ development. Over the past few years, emerging studies have identified that mRNA m<jats:sup>6<\/jats:sup>A regulators defect in \u03b2\u2010cell leads to abnormal regulation of the target mRNAs, thereby resulting in \u03b2\u2010cell dysfunction and loss of \u03b2\u2010cell identity and mass, which are strongly associated with type 2 diabetes mellitus (T2DM) pathogenesis. Also, mRNA m<jats:sup>6<\/jats:sup>A modification has been implicated with insulin resistance in muscles, fat, and liver cells\/tissues. In this review, we elaborate on the biological features of m<jats:sup>6<\/jats:sup>A methylation; provide a comprehensive overview of the underlying mechanisms that how it controls \u03b2\u2010cell function, identity, and mass as well as insulin resistance; highlight its connections to glucose metabolism and lipid metabolism linking to T2DM; and further discuss its role in diabetes complications and its therapeutic potentials for T2DM diagnosis and treatment.<\/jats:p>","DOI":"10.1111\/obr.13639","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T09:19:28Z","timestamp":1695287968000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["m<sup>6<\/sup>A mRNA methylation: Biological features, mechanisms, and therapeutic potentials in type 2 diabetes mellitus"],"prefix":"10.1111","volume":"24","author":[{"given":"Yuanyuan","family":"Ren","sequence":"first","affiliation":[{"name":"Key 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