{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:16:22Z","timestamp":1787015782618,"version":"build-2736575974"},"reference-count":72,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Bariatric surgery can cause numerous functional changes to recipients, some of which are unintended. However, a systematic evaluation of wide\u2010angled health benefits and risks following bariatric surgery has not been conducted. We systematically evaluated published systematic reviews of randomized controlled trials and observational studies reporting the association between bariatric surgery and health outcomes. We performed subgroup analyses by surgery type and sensitivity analysis, excluding gastric band. Thirty systematic reviews and 82 meta\u2010analyzed health outcomes were included in this review. A total of 66 (80%) health outcomes were significantly associated with bariatric surgery, of which 10 were adverse outcomes, including suicide, fracture, gastroesophageal reflux after sleeve gastrectomy, and neonatal morbidities. The other 56 outcomes were health benefits including new\u2010onset diabetes mellitus (DM) (odds ratio [OR]\u2009=\u00a00.39; 95% confidence interval [CI]\u2009=\u00a00.19\u20130.79), hypertension (OR\u2009=\u00a00.36; 95% CI\u2009=\u00a00.33\u20130.40), dyslipidemia (OR\u2009=\u00a00.33; 95% CI\u2009=\u00a00.14\u20130.81), cancers (OR\u2009=\u00a00.65; 95% CI\u2009=\u00a00.53\u20130.80), cardiovascular diseases (CVDs), and women's health. Surgery is associated with reductions in all\u2010cause mortality and death due to cancer, DM, and CVD. Bariatric surgery has both beneficial and harmful effects on a broader than expected array of patients' health outcomes. An expansion of the indication for bariatric surgery could be discussed to include a broader population with metabolic vulnerabilities.<\/jats:p>","DOI":"10.1111\/obr.13670","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T21:24:12Z","timestamp":1701725052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Association of bariatric surgery with indicated and unintended outcomes: An umbrella review and meta\u2010analysis for risk\u2013benefit assessment"],"prefix":"10.1111","volume":"25","author":[{"given":"Min Seo","family":"Kim","sequence":"first","affiliation":[{"name":"Samsung Advanced Institute for Health Sciences &amp; Technology (SAIHST) Sungkyunkwan University, Samsung Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Yeob","family":"Kim","sequence":"additional","affiliation":[{"name":"Samsung Advanced Institute for Health Sciences &amp; Technology (SAIHST) Sungkyunkwan University, Samsung Medical Center  Seoul Republic of Korea"},{"name":"College of Medicine Yonsei University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Shin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Medicine Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seokwon","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Medicine Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Hee","family":"Won","sequence":"additional","affiliation":[{"name":"Samsung Advanced Institute for Health Sciences &amp; Technology (SAIHST) Sungkyunkwan University, Samsung Medical Center  Seoul Republic of Korea"},{"name":"Samsung Genome Institute Samsung Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Gangneung Prison Medical Department Ministry of Justice  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeongkeun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Foregut Surgery Korea University College of Medicine  Seoul Republic of Korea"},{"name":"Centre for Obesity and Metabolic Diseases Korea University Anam Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Medicine Korea University College of Medicine  Seoul Republic of Korea"},{"name":"Centre for Obesity and Metabolic Diseases Korea University Anam Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess G.","family":"Fiedorowicz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Ottawa  Ottawa Ontario Canada"},{"name":"Department of Mental Health The Ottawa Hospital  Ottawa Ontario Canada"},{"name":"Ottawa Hospital Research Institute (OHRI) Clinical Epidemiology Program University of Ottawa  Ottawa Ontario Canada"},{"name":"School of Epidemiology and Public Health, Faculty of Medicine University of Ottawa  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Solmi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Ottawa  Ottawa Ontario Canada"},{"name":"Department of Mental Health The Ottawa Hospital  Ottawa Ontario Canada"},{"name":"Ottawa Hospital Research Institute (OHRI) Clinical Epidemiology Program University of Ottawa  Ottawa Ontario Canada"},{"name":"School of Epidemiology and Public Health, Faculty of Medicine University of Ottawa  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2326-1820","authenticated-orcid":false,"given":"Jae Il","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine Yonsei University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1779-8683","authenticated-orcid":false,"given":"Sungsoo","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Foregut Surgery Korea University College of Medicine  Seoul Republic of Korea"},{"name":"Centre for Obesity and Metabolic Diseases Korea University Anam Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul J.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Department of General Surgery and the Bariatric and Metabolic Institute Cleveland Clinic Florida  Weston Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)32822\u20108"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2024212"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(14)61748\u20107"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600869"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.21055"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(15)00075\u20106"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010018\u20103593\u20101"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14829"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esxm.2019.06.003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12567"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab454"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010019\u201000505\u20106"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental\u20102018\u2010300014"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00591\u20102"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.10706"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197\u20102456(86)90046\u20102"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m3502"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.04.016"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2016.05.003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010019\u201004083\u20100"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2307\/3001666"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u2010985X.2008.00552.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1745691614553988"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1037\/met0000025"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006\u2010341X.2000.00455.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v036.i03"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4008"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059202"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjebm\u20102019\u2010111191"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.7326\/M19\u20100341"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l2368"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j5024"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(19)30422\u2010X"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g5630"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz388"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23722"},{"key":"e_1_2_9_41_1","article-title":"Causal effect of adiposity on the risk of 19 gastrointestinal diseases: a Mendelian randomization study","author":"Kim MS","year":"2021","journal-title":"medRxiv"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010023\u201003001\u20107"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djab102"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010022\u201002060\u20106"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003679"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1016613"},{"issue":"4","key":"e_1_2_9_47_1","first-page":"3","article-title":"CDC National Health Report: leading causes of morbidity and mortality and associated behavioral risk and protective factors\u2014United States, 2005\u20132013","volume":"63","author":"Johnson NB","year":"2014","journal-title":"MMWR Suppl"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j477"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12932"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i1472"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.4865"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.12.004"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.1813"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2019.1632132"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.48"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u2010789X.2012.01050.x"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12706"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1401329"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.18118"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(17)30437\u20100"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010018\u20100006\u20104"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12998"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12014"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12926"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.07.028"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1405789"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102019\u2010319620"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12927"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13201"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011740.pub2"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.81"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1300625"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000993"}],"container-title":["Obesity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/obr.13670","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:53:50Z","timestamp":1721091230000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/obr.13670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,4]]},"references-count":72,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/obr.13670"],"URL":"https:\/\/doi.org\/10.1111\/obr.13670","archive":["Portico"],"relation":{},"ISSN":["1467-7881","1467-789X"],"issn-type":[{"value":"1467-7881","type":"print"},{"value":"1467-789X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,4]]},"assertion":[{"value":"2022-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13670"}}