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However, the pathogenesis of fetal\u2010originated is still lacking in a theoretical system, which makes its clinical early prevention and treatment difficult. It has been found that an adverse environment during pregnancy (e.g., xenobiotic exposure) may lead to changes in fetal blood cholesterol levels through changing maternal cholesterol metabolic function and\/or placental cholesterol transport function and may also directly affect the liver cholesterol metabolic function of the offspring in utero and continue after birth. Adverse environmental conditions during pregnancy may also raise maternal glucocorticoid levels and promote the placental glucocorticoid barrier opening, leading to fetal overexposure to maternal glucocorticoids. Intrauterine high\u2010glucocorticoid exposure can alter the liver cholesterol metabolism of offspring, resulting in an increased susceptibility to hypercholesterolemia after birth. Abnormal epigenetic modifications are involved in the intrauterine programming mechanism of fetal\u2010originated hypercholesterolemia. Some interventions targeted at pregnant mothers or offspring in early life have been proposed to effectively prevent and treat the development of fetal\u2010originated hypercholesterolemia. In this paper, the recent research progress on fetal\u2010originated hypercholesterolemia was reviewed, with emphasis on intrauterine maternal glucocorticoid programming mechanisms, in order to provide a theoretical basis for its early clinical warning, prevention, and treatment.<\/jats:p>","DOI":"10.1111\/obr.13672","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T08:24:54Z","timestamp":1702110294000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Intrauterine developmental origin, programming mechanism, and prevention strategy of fetal\u2010originated hypercholesterolemia"],"prefix":"10.1111","volume":"25","author":[{"given":"Kexin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pharmacology Wuhan University School of Basic Medical Sciences  Wuhan China"},{"name":"Department of Pharmacy Zhongnan Hospital of Wuhan University  Wuhan 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