{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:50:14Z","timestamp":1790117414604,"version":"4.0.1"},"reference-count":72,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:00:00Z","timestamp":1707609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:00:00Z","timestamp":1707609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Weight loss is recommended for individuals with obstructive sleep apnea (OSA) and overweight or obesity, but there is limited evidence to guide the selection of weight management strategies for patients who do not lose sufficient weight with diet and lifestyle changes. We evaluated the relationship between weight loss caused by pharmacologic or surgical interventions and subsequent improvement in OSA by the apnea\u2010hypopnea index (AHI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Cochrane CENTRAL, and EMBASE were searched for randomized trials comparing pharmacologic or surgical obesity interventions to usual care, placebo, or no treatment in adults with OSA. The association between percentage weight loss and AHI change between randomization and last follow\u2010up was evaluated using meta\u2010regression. PROSPERO: CRD42022378853.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ten eligible trials (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u2009854 patients) were included. Four (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u2009211) assessed bariatric surgery, and 6 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u2009643) assessed pharmacologic interventions over a median follow\u2010up of 13\u2009months (interquartile range 6\u201326\u2009months). The linear best estimate of the change in AHI is 0.45 events per hour (95% Confidence Interval 0.18 to 0.73 events per hour) for every 1% body weight lost.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Weight loss caused by medication or surgery caused a proportionate improvement of the AHI. Providers could consider extrapolating from this relationship when advising patients of the expected effects of other pharmacologic or surgical interventions without direct evidence in OSA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/obr.13697","type":"journal-article","created":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T22:29:13Z","timestamp":1707690553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The association of weight loss from anti\u2010obesity medications or bariatric surgery and apnea\u2010hypopnea index in obstructive sleep apnea"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3588-5238","authenticated-orcid":false,"given":"Brian W.","family":"Locke","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care, Department of Internal Medicine University of Utah  Salt Lake City Utah 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