{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:09:22Z","timestamp":1791994162799,"version":"4.4.0"},"reference-count":60,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    This systematic review and meta\u2010analysis evaluated the efficacy of anti\u2010obesity agents for hormonal, reproductive, metabolic, and psychological outcomes in polycystic ovary syndrome (PCOS) to inform the 2023 update of the International Evidence\u2010based Guideline on PCOS. We searched Medline, EMBASE, PsycInfo, and CINAHL until July 2022 with a 10\u2010year limit to focus on newer agents. Eleven trials (545 and 451 participants in intervention and control arms respectively, 12 comparisons) were included. On descriptive analyses, most agents improved anthropometric outcomes; liraglutide, semaglutide and orlistat appeared superior to placebo for anthropometric outcomes. Meta\u2010analyses were possible for two comparisons (exenatide vs. metformin and orlistat\u2009+\u2009combined oral contraceptive pill [COCP] vs. COCP alone). On meta\u2010analysis, no differences were identified between exenatide versus metformin for anthropometric, biochemical hyperandrogenism, and metabolic outcomes, other than lower fasting blood glucose more with metformin than exenatide (MD: 0.10\u00a0mmol\/L, CI 0.02\u20130.17,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u200918%, 2 trials). Orlistat\u2009+\u2009COCP did not improve metabolic outcomes compared with COCP alone (fasting insulin MD: \u22128.65\u2009pmol\/L, \u221233.55 to 16.26,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u200967%, 2 trials). Published data examining the effects of anti\u2010obesity agents in women with PCOS are very limited. The role of these agents in PCOS should be a high priority for future research.\n                  <\/jats:p>","DOI":"10.1111\/obr.13704","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T22:44:23Z","timestamp":1707950663000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Anti\u2010obesity pharmacological agents for polycystic ovary syndrome: A systematic review and meta\u2010analysis to inform the 2023 international evidence\u2010based guideline"],"prefix":"10.1111","volume":"25","author":[{"given":"Alyse","family":"Goldberg","sequence":"first","affiliation":[{"name":"Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Graca","sequence":"additional","affiliation":[{"name":"School of Health and Society, Faculty of Education, Health and Wellbeing University of Wolverhampton  Wolverhampton West Midlands UK"},{"name":"Department of Research Northern College of Acupuncture  York North Yorkshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"NICM Health Research Institute Western Sydney University  Penrith New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibhuti","family":"Rao","sequence":"additional","affiliation":[{"name":"NICM Health Research Institute Western Sydney University  Penrith New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma Feldman","family":"Witchel","sequence":"additional","affiliation":[{"name":"UPMC Children's Hospital of Pittsburgh University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia","family":"Pena","sequence":"additional","affiliation":[{"name":"Discipline of Paediatrics, Robinson Research Institute The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of OB &amp; GYN, Reproductive Medical Center Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7356-4523","authenticated-orcid":false,"given":"Aya","family":"Mousa","sequence":"additional","affiliation":[{"name":"Monash Centre for Health Research and Implementation Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chau Thien","family":"Tay","sequence":"additional","affiliation":[{"name":"Monash Centre for Health Research and Implementation Monash University  Melbourne Victoria Australia"},{"name":"Department of Diabetes and Vascular Medicine Monash Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loyal","family":"Pattuwage","sequence":"additional","affiliation":[{"name":"Monash Centre for Health Research and Implementation Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7609-577X","authenticated-orcid":false,"given":"Helena","family":"Teede","sequence":"additional","affiliation":[{"name":"Monash Centre for Health Research and Implementation Monash University  Melbourne Victoria Australia"},{"name":"Department of Diabetes and Vascular Medicine Monash Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulent O.","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3363-9199","authenticated-orcid":false,"given":"Carolyn","family":"Ee","sequence":"additional","affiliation":[{"name":"NICM Health Research Institute Western Sydney University  Penrith New South Wales Australia"},{"name":"Translational Health Research Institute Western Sydney University  Penrith New South Wales Australia"},{"name":"Caring Futures Institute Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(22)00163\u20102"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa839"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.05.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad463"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2023.2282689"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23084334"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20213"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnac001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003132"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.11.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007506.pub4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2015.01.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902\u2010022\u201001208\u2010y"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d7771"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.20.4.270.34882"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1R501"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.461"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2015.1096345"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004\u20102283"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7421.951"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/20420188221127142"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_8_24_1","unstructured":"Covidence systematic review software.2022. 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