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Pharmacological or surgical interventions were excluded. Study quality was evaluated using the Cochrane Risk of Bias Tool. Interventions were grouped as dietary, physical activity, education\/coaching, or multi\u2010component. Mean weight changes, standard deviations, confidence intervals, and effect sizes were extracted or calculated for assessment of the intervention effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty studies involving 6,511 participants were included in the qualitative synthesis. Most studies (<jats:italic>n<\/jats:italic>\u00a0=\u200932) included multi\u2010component interventions, incorporating dietary and physical activity components. Limited evidence suggests that extensive dietary interventions or long\u2010term multi\u2010component interventions might lead to a clinically relevant weight reduction of at least 5% for older individuals (age &gt; 50) with mild\u2010to\u2010moderate mobility impairments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Due to the high heterogeneity of studies and low study quality, it can be assumed that the range of applicability of the findings is questionable. Further research should examine younger age groups (i.e., children, adolescents, and adults under 40\u2009years) and compare different settings such as schools, clinics, nursing homes, and assisted living facilities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/obr.13722","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T04:34:15Z","timestamp":1707453255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Behavioral weight loss interventions for people with physical disabilities: A systematic review"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5735-7145","authenticated-orcid":false,"given":"Jihad","family":"Hossaini","sequence":"first","affiliation":[{"name":"Chair of Social Determinants of Health, School of Medicine and Health, Department Health and Sport Sciences Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0650-4333","authenticated-orcid":false,"given":"Vanesa","family":"Osmani","sequence":"additional","affiliation":[{"name":"Chair of Epidemiology, School of Medicine and Health, Department Health and Sport Sciences Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3523-1362","authenticated-orcid":false,"given":"Stefanie J.","family":"Klug","sequence":"additional","affiliation":[{"name":"Chair of Epidemiology, School of Medicine and Health, Department Health and Sport Sciences Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO.Disability. 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