{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:19:09Z","timestamp":1790601549475,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Weight regain and insufficient weight loss are major challenges after metabolic bariatric surgery (MBS), affecting patients' comorbidities and quality of life. The current systematic review and meta\u2010analysis aim to assess the efficacy and safety of GLP\u20101 receptor agonists (GLP\u20101 RA) in patients with weight regain or insufficient weight loss after MBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search was conducted across PubMed, Embase, Scopus, and Web of Science databases to find the relevant studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 19 articles were included. The highest doses of liraglutide and semaglutide were 3\u00a0mg per day and 1\u00a0mg once weekly, respectively, in the included studies. The mean differences in weight and body mass index after treatment were \u22127.02\u2009kg or 3.07\u2009kg\/m<jats:sup>2<\/jats:sup>, \u22128.65 or \u22125.22\u2009kg\/m<jats:sup>2<\/jats:sup>, and \u22126.99\u2009kg or \u22123.09\u2009kg\/m<jats:sup>2<\/jats:sup> for treatment durations of \u2264 6\u00a0months, 6\u201312\u2009months, and &gt;12\u2009months with liraglutide, respectively. Additionally, weekly semaglutide showed significantly greater weight loss compared to daily liraglutide, with a mean difference of 4.15\u2009kg. Common complications included nausea (19.1%), constipation (8.6%), abdominal pain (3.7%), and vomiting (2.4%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using GLP\u20101 RA is a safe and effective treatment for weight regain and insufficient weight loss after MBS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/obr.13811","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:09:20Z","timestamp":1723507760000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Safety and efficacy of glucagon\u2010like peptide\u20101 (GLP\u20101) receptor agonists in patients with weight regain or insufficient weight loss after metabolic bariatric surgery: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"25","author":[{"given":"Ali","family":"Esparham","sequence":"first","affiliation":[{"name":"Student Research Committee, School of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Mehri","sequence":"additional","affiliation":[{"name":"Endoscopic and Minimally Invasive Surgery Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Dalili","sequence":"additional","affiliation":[{"name":"Department of General Surgery, School of Medicine, Surgical Oncology Research Center, Imam Reza Hospital Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Richards","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Oklahoma School of Community Medicine  Tulsa Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6144-691X","authenticated-orcid":false,"given":"Zhamak","family":"Khorgami","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Oklahoma  School of Community Medicine Tulsa Oklahoma USA"},{"name":"Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010021\u201008329\u2010w"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1700459"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102020\u2010046407"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010023\u201006913\u20108"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23736"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.3654"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010014\u20101216\u2010z"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010016\u20102201\u20105"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010018\u20103245\u20105"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2020.04.009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010020\u201004856\u2010y"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010019\u201004111\u2010z"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010009\u20100066\u20106"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15271"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.5.597"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20\u20100720"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101351"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.23736\/S2724\u20106507.20.03369\u20106"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.05.007"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.12.035"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010015\u20101908\u2010z"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010023\u201006484\u20108"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.23619"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.807548"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2013.162"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12932"},{"key":"e_1_2_8_28_1","unstructured":"Group QATfB\u2010AP\u2010PSWNC.https:\/\/www.nhlbi.nih.gov\/health-topics\/study-quality-assessment-tools"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102288\u20105\u201013"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280216669183"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102288\u201014\u2010135"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2016.02.013"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.obpill.2023.100098"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010018\u20103393\u20107"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/osp4.706"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010021\u201005535\u20102"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519\u2010022\u201001403\u20109"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1183899"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010021\u201005884\u2010y"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010022\u201006211\u20109"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23922"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423\u2010023\u201002805\u20108"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2023.2930"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(19)30157\u20103"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100\u201069912013000300005"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13672"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12323"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.9676"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)31773\u20102"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1159\/000518325"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(09)61375\u20101"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010020\u201001337\u20107"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300\u2010019\u201000736\u20106"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23752"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18\u20100567"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607141"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)31271\u20101"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00213\u20100"},{"key":"e_1_2_8_60_1","unstructured":"ClinicalTrials.gov.Semaglutide 2.4 mg in patients with poor weight\u2010loss (BARI\u2010STEP). Betheseda (MD: National Library of Medicine US). Accessed August 23 2022. NCT05073835. Available at:https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05073835"}],"container-title":["Obesity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/obr.13811","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T23:21:03Z","timestamp":1749597663000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/obr.13811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,12]]},"references-count":59,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/obr.13811"],"URL":"https:\/\/doi.org\/10.1111\/obr.13811","archive":["Portico"],"relation":{},"ISSN":["1467-7881","1467-789X"],"issn-type":[{"value":"1467-7881","type":"print"},{"value":"1467-789X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,12]]},"assertion":[{"value":"2023-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13811"}}