{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:14:42Z","timestamp":1793726082321,"version":"4.6.1"},"reference-count":57,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373773"],"award-info":[{"award-number":["82373773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073748"],"award-info":[{"award-number":["82073748"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81741130"],"award-info":[{"award-number":["81741130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study aimed to evaluate the efficacy and safety of duodenal\u2013jejunal bypass liner (DJBL) for obesity and type 2 diabetes mellitus. A comprehensive search of electronic databases was conducted up to September 15, 2022. Thirty studies involving 1751 patients were included. At 12\u2009months post\u2010implantation, the reduction in body mass index (BMI) was 4.8\u2009kg\/m<jats:sup>2<\/jats:sup> (95% CI 4.1, 5.5), with an excess weight loss of 41.3% (95% CI 33.4%,49.2%) and a total weight loss of 13.1% (95% CI 10.1%, 16.0%). Significant decrease was observed in HbA1c and fasting glucose, with a standardized mean difference of \u2212 0.72 (95% CI \u2212 0.95, \u2212 0.48) and \u2212 0.62 (95% CI \u2212 0.82, \u2212 0.42), respectively. However, these improvements in weight loss and glycemic control were only partially sustained after explantation. In situ, DJBL significantly improves blood pressure and lipid levels. The pooled early removal rate was 19%, and the incidence of severe adverse events was 17%, including device migration (6%), gastrointestinal hemorrhage (4%), device obstruction (4%), and hepatic abscess (2%). DJBL offers significant improvement in weight loss and glycemic control, as well as cardiovascular parameters while in situ. Further studies are warranted to better understand the long\u2010term efficacy and safety of DJBL. The benefits of DJBL need to be carefully weighed against the risks in clinical decision\u2010making.<\/jats:p>","DOI":"10.1111\/obr.13812","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:28:58Z","timestamp":1724804938000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and safety of duodenal\u2013jejunal bypass liner for obesity and type 2 diabetes: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8206-0733","authenticated-orcid":false,"given":"Wenhui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Metabolic and Bariatric Surgery The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Feng","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Department of Cellular Biology Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiliang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Metabolic and Bariatric Surgery The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Metabolic and Bariatric Surgery The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Metabolic and Bariatric Surgery The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songhao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Metabolic and Bariatric Surgery The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Metabolic and Bariatric Surgery The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunchuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Metabolic and Bariatric Surgery The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Department of Cellular Biology Jinan University  Guangzhou China"},{"name":"Key laboratory of Bioengineering Medicine of Guangdong Province Jinan University  Guangzhou China"},{"name":"The National Demonstration Center for Experimental Education of Life Science and Technology Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Metabolic and Bariatric Surgery The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(22)01280\u20106"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010018\u20103525\u20100"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.08.022"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.51179"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010018\u20103123\u20101"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010016\u20105299\u20106"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000000794"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2018.07.022"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2015.03.1911"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010018\u20103441\u20103"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12603"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17\u20101985"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010022\u201006379\u20100"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010010\u20109491\u2010z"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197\u20102456(95)00134\u20104"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.13770"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1214\/aoms\/1177729756"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049\u20103258\u201072\u201039"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.08.017"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000004980"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004339"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2007.07.012"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2009.0063"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010008\u20100125\u20104"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2009.11.051"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181bdfbff"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2011.0152"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31825498c4"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12268"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010013\u20100921\u20103"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100042\u2010118961"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1530\/joe\u201016\u20100206"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2016.07.027"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010017\u20102939\u20104"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010016\u20102311\u20100"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13300"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010017\u20105672\u20100"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010017\u20102997\u20107"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010018\u20103322\u20109"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.15277\/bjd.2019.226"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3287"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010019\u201004279\u20104"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.10.026"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010022\u201009177\u2010y"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.14409"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100034\u20101366570"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010019\u201006752\u20108"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010018\u201003659\u20106"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14827"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14725"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.3224"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010019\u201004324\u20102"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22\u20101952"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7823182"}],"container-title":["Obesity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/obr.13812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T23:21:15Z","timestamp":1749597675000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/obr.13812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,27]]},"references-count":57,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/obr.13812"],"URL":"https:\/\/doi.org\/10.1111\/obr.13812","archive":["Portico"],"relation":{},"ISSN":["1467-7881","1467-789X"],"issn-type":[{"value":"1467-7881","type":"print"},{"value":"1467-789X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,27]]},"assertion":[{"value":"2022-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13812"}}