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It exerts its effects by triggering various signaling pathways, enhancing the production of pro\u2010inflammatory cytokines and nitric oxide (NO), as well as promoting immune cells infiltration and \u03b2\u2010cells death. Abnormal alterations in IL\u201018 levels have been revealed to be strongly associated with the onset and development of DM and its complications. Targeting IL\u201018 may present a novel and promising approach for DM therapy. An increasing number of IL\u201018 inhibitors, including chemical and natural inhibitors, have been developed and have been shown to protect against DM and diabetic complications. This review provides a comprehensive understanding of the production, biological functions, action mode, and activated signaling pathways of IL\u201018. Next, we shed light on how IL\u201018 contributes to the pathogenesis of DM and its associated complications with links to its roles in the modulation of \u03b2\u2010cell failure and death, insulin resistance in various tissues, and pancreatitis. Furthermore, the therapeutic potential of targeting IL\u201018 for the diagnosis and treatment of DM is also highlighted. We hope that this review will help us better understand the functions of IL\u201018 in the pathogenesis of DM and its complications, providing novel strategies for DM diagnosis and treatment.<\/jats:p>","DOI":"10.1111\/obr.13818","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T20:15:13Z","timestamp":1724789713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Deciphering interleukin\u201018 in diabetes and its complications: Biological features, mechanisms, and therapeutic perspectives"],"prefix":"10.1111","volume":"25","author":[{"given":"Runlin","family":"Gui","sequence":"first","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine Northwest University  Xi'an Shaanxi China"},{"name":"Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases Xi'an No.3 Hospital, 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