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This study aims to estimate the global prevalence of mild cognitive impairment (MCI) and dementia in elderly aged 60\u2009years or above with overweight, obesity, and central obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, Embase, Web of Science, and Cochrane Library from inception to November 2023. DerSimonian\u2010Laird random\u2010effects model with Logit transformation was used. Sensitivity analysis, meta\u2010regression, and subgroup analysis were employed to investigate determinants of the prevalence of MCI and dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 72 studies involving 2,980,947 elderly with distinct adiposity status were included. Pooled prevalence of MCI and dementia in elderly with overweight and obesity was 32.54% and 9.47%, respectively. Univariate meta\u2010regression analysis indicated that the heterogeneity in dementia prevalence was attributable to variations in study size (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.01,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), while the multivariable analysis underscored that the income of country or area had the most significant predictive importance (60.3% and 90.3%) for both MCI and dementia prevalence. Subgroup analysis revealed regional disparities and diagnostic technique variations contributing to heterogeneity. Based on currently available but inadequate epidemiological data, the pooled prevalence of MCI and dementia in elderly with central obesity was calculated as 10.18% and 9.75%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Strategies to address adiposity\u2010associated cognitive impairment should consider multifaceted interventions beyond simple weight reduction. Macro\u2010level initiatives such as improvement of income levels and micro\u2010level interventions including the adoption of accurate diagnostic techniques also represent equally pivotal components.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/obr.13882","type":"journal-article","created":{"date-parts":[[2024,12,8]],"date-time":"2024-12-08T20:09:31Z","timestamp":1733688571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Estimating global prevalence of mild cognitive impairment and dementia in elderly with overweight, obesity, and central obesity: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1380-1755","authenticated-orcid":false,"given":"Junlun","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Research Center for Islet Transplantation, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Research Center for Islet Transplantation, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaye","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Thyroid Surgery, Department of General Surgery, West China Hospital Sichuan University  Chengdu China"},{"name":"Laboratory of Thyroid and Parathyroid Diseases, Frontiers Science Center for Disease\u2010Related Molecular Network, West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Respiratory and Critical Care Medicine, Frontiers Science Center for Disease\u2010related Molecular Network, Center of Precision Medicine, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Research Center for Islet Transplantation, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery University Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery University Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu 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