{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:36:20Z","timestamp":1783593380352,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Currently, trials are investigating the efficacy of nutrient\u2010stimulated hormone\u2010based therapies (NuSHs) in promoting weight loss in people living with overweight and obesity. However, the extent to which nutritional and functional outcomes are evaluated remains uncertain. Thus, we conducted a systematic mapping to assess the presence of nutritional and functional outcomes in randomized controlled trials (RCTs) investigating NuSHs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a systematic mapping search on the Cochrane Central Register of Controlled Trials (CENTRAL), which includes <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> and the International Clinical Trials Registry Platform for interventional trials of NuSHs registered from inception to December 31, 2023. We excluded non\u2010 and quasi\u2010randomized trials, phase I trials, trials that did not include body weight as a primary or secondary outcome, trials with an intervention duration of less than 6\u00a0months, and trials that did not specify a body mass index threshold in their eligibility criteria. Outcomes included: dietary intake, eating behavior, body composition, physical performance, muscle strength, bone health, and levels of vitamins, trace elements, albumin, prealbumin, and hemoglobin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The search identified 2284 trials, of which 417 were included in the analysis. The proportion of RCTs that included nutritional assessment other than body weight increased over time. Approximately, 20.4% reported measurements of body composition, 17.3% reported measurements of albumin\/prealbumin\/hemoglobin, and 17% reported assessment of dietary intake and eating behavior. Evaluations of bone health, physical performance, muscle strength, and measurements of vitamins\/trace elements were reported in less than 5% of the total trials each.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present review has shown the sparse reporting of nutritional and functional outcomes in RCTs evaluating the impact of NuSHs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/obr.13890","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T08:52:05Z","timestamp":1737967925000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Nutritional and functional outcomes in trials of nutrient\u2010stimulated hormone\u2010based therapy\u2014A systematic mapping review"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7353-2532","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Czernichow","sequence":"first","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP), Service de Nutrition, Centre Sp\u00e9cialis\u00e9 Ob\u00e9sit\u00e9 H\u00f4pital Europ\u00e9en Georges Pompidou  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"INSERM, UMR1153, Epidemiology and Biostatistics Sorbonne Paris Cit\u00e9 Center (CRESS), METHODS team  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7987-8219","authenticated-orcid":false,"given":"Nathalie","family":"Rassy","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP), Service de Nutrition, Centre Sp\u00e9cialis\u00e9 Ob\u00e9sit\u00e9 H\u00f4pital Europ\u00e9en Georges Pompidou  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8175-0369","authenticated-orcid":false,"given":"Claire","family":"Carette","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP), Service de Nutrition, Centre Sp\u00e9cialis\u00e9 Ob\u00e9sit\u00e9 H\u00f4pital Europ\u00e9en Georges Pompidou  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1780-1627","authenticated-orcid":false,"given":"Nicholas","family":"Shoung","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP), Service de Nutrition, Centre Sp\u00e9cialis\u00e9 Ob\u00e9sit\u00e9 H\u00f4pital Europ\u00e9en Georges Pompidou  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8412-2261","authenticated-orcid":false,"given":"Frank B.","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health  Boston MA USA"},{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"},{"name":"Department of Epidemiology Harvard T.H. 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