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The aim of this paper was to carry out a systematic review with meta\u2010analysis on cryolipolysis and associated health outcomes, adverse events (AE) and patient satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Major databases were searched from inception until April 4, 2024. Meta\u2010analysis was performed using random\u2010effect models to calculate the pooled effects size and 95% confidence interval (CI) of each finding. The systematic review protocol was registered on PROSPERO, CRD\u201042024548077.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 30 studies were included, including 3158 participants. The result of meta\u2010analyses showed reduced body mass index (mean differences [MD]\u2009=\u2009\u22121.80, 95% confidence interval [CI] \u22122.98, \u22120.62, <jats:italic>p<\/jats:italic>\u2009=\u20090.0003), waist\u2010to\u2010hip ratio (MD\u2009=\u2009\u22120.09, 95% CI \u22120.16, \u22120.02, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), mean abdominal circumference (cm) (MD\u2009=\u2009\u22123.56, 95% CI \u22124.98, \u22122.15, <jats:italic>p<\/jats:italic>\u2009=\u20090.000001), and mean suprailiac fat thickness (FT) (mm) (MD\u2009=\u2009\u22125.22, 95% CI \u22129.03, \u22121.42, <jats:italic>p<\/jats:italic>\u2009=\u20090.0007), 12\u2009weeks after cryolipolysis as compared with baseline values. The satisfaction rate was 80.4% and the AE of cryolipolysis was 49.5% for numbness, 44.5% for erythema, 30.5% for edema, 28.8% for pain, 25.4% for sensitivity, 15.2% for tingling, and 2% for hyperpigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the present study, it was found that cryolipolysis was associated with a reduction in the number of adiposity parameters at 3\u00a0months follow\u2010up. A relatively high level of minor AEs was reported; however, patient satisfaction was high suggesting that the treatment is well tolerated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/obr.13925","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T04:24:22Z","timestamp":1744345462000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cryolipolysis and associated health outcomes, adverse events, and satisfaction: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"26","author":[{"given":"Roshan","family":"Ravindran","sequence":"first","affiliation":[{"name":"KLNIK, The Colony, Wilmslow  Cheshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4122-0774","authenticated-orcid":false,"given":"Damiano","family":"Pizzol","sequence":"additional","affiliation":[{"name":"Health Unit, Eni  San Donato Milanese 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