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Indeed, adipose tissue inflammation, which partially stems from macrophage infiltration and expression of macrophage\u2010derived cytokines, has local and systemic consequences on health and increases the likelihood of developing obesity\u2010associated comorbidities. In addition, cellular changes driven by macrophages may also further aggravate both adipose tissue dysfunction and inflammation, thus contributing to the onset and progression of several comorbidities including type 2 diabetes, cardiovascular diseases, nonalcoholic fatty liver disease, osteoarthritis, some cancers, and dementia. 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