{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:11:28Z","timestamp":1790957488938,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["303041"],"award-info":[{"award-number":["303041"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Next\u2010generation incretin therapies, including semaglutide and tirzepatide, have transformed obesity and Type 2 diabetes management. However, evidence\u2010based nutritional strategies to support safe and effective use of these agents remain limited. To address this gap, we conducted a systematic scoping review across five databases of studies published between January 2015 and April 2025 to map and appraise clinical trials incorporating nutritional interventions or dietary assessments during semaglutide or tirzepatide therapy in adults with obesity or Type 2 diabetes. Eligible studies included adults receiving semaglutide or tirzepatide with either an active dietary intervention or measured nutrition\u2010related outcomes. Study quality was assessed using established tools. Twelve studies were included: 10 randomized controlled trials, one non\u2010randomized comparative study, and one cross\u2010sectional observational study. Interventions ranged from structured very\u2010low\u2010energy or ketogenic diets to general lifestyle counseling and observational dietary assessments. Across studies, energy intake decreased by 24% to 39%, but lean tissue loss accounted for up to 40% of total weight reduction. Only three studies involved nutrition professionals, and systematic assessment of protein or micronutrient intake was rare. One observational study found widespread nutrient inadequacies and limited access to dietetic support. Despite the effectiveness of semaglutide and tirzepatide for weight loss, evidence on optimal dietary strategies is sparse. Early dietitian involvement, high\u2010protein, nutrient\u2010dense diets, and routine nutritional monitoring should be prioritized. Robust trials are needed to define best practice for integrating dietary care alongside pharmacotherapy.<\/jats:p>","DOI":"10.1111\/obr.70079","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:02:24Z","timestamp":1767830544000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Nutrition Strategies for Next\u2010Generation Incretin Therapies: A Systematic Scoping Review of the Current Evidence"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8346-2408","authenticated-orcid":false,"given":"Marie","family":"Spreckley","sequence":"first","affiliation":[{"name":"MRC Epidemiology Unit University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6498-991X","authenticated-orcid":false,"given":"Cara\u00a0F.","family":"Ruggiero","sequence":"additional","affiliation":[{"name":"MRC Epidemiology Unit University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1818-6192","authenticated-orcid":false,"given":"Adrian","family":"Brown","sequence":"additional","affiliation":[{"name":"Centre for Obesity Research University College London  Longdon UK"},{"name":"Bariatric Centre for Weight Management and Metabolic Surgery University College London Hospital NHS Foundation Trust  London UK"},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206034"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2311129"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2416394"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13029"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14261"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.obpill.2024.100121"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nbu.12534"},{"key":"e_1_2_14_10_1","unstructured":"British Dietetic Association & British Nutrition Foundation.2024.Joint Position Statement Regarding GLP\u20101\/GIP Receptor Agonists in People Living With Obesity and\/or Type 2 Diabetes https:\/\/www.nutrition.org.uk\/news\/joint\u2010position\u2010statement\u2010regarding\u2010glp\u20101gip\u2010receptor\u2010agonists."},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajcnut.2025.04.023"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.24067"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S494919"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13960"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22\u20102297"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12970\u2010017\u20100174\u2010y"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14537"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.3604"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)32332\u20101"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21093"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1566498"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2018.05.021"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13041352"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17071216"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(24)30103\u20106"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304238"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.2982"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(23)30476\u2010X"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2024.03.007"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.21057"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)33102\u20101"},{"key":"e_1_2_14_34_1","unstructured":"National Institute for Health and Care Excellence \u201cObesity: Identification Assessment and Management. 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