{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:48:42Z","timestamp":1789076922424,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2009050"],"award-info":[{"award-number":["2009050"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>While the association between metabolic factors and risk of colorectal cancer (CRC) in the general population is well established, their effect on precancerous polyps among individuals undergoing surveillance colonoscopy is not well understood. Additionally, most guidelines do not consider metabolic factors when determining surveillance colonoscopy intervals. This systematic review and meta\u2010analysis summarizes current evidence for this association in individuals at above\u2010average risk for CRC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Relevant studies published from 2010 through 2023 were identified using seven databases. Two independent reviewers performed abstract and full\u2010text screening and quality assessment. Effect estimates were reported using a pooled odds ratio (POR) or pooled hazard ratio (PHR) based on the primary studies measurement with 95% confidence intervals and heterogeneity was reported as\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      15,486 studies were screened, with 24 meeting the inclusion criteria. General obesity (POR\u2009=\u20091.31, 95% CI 1.09\u20131.57,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200967%), central obesity (POR\u2009=\u20091.31, 95% CI 1.16\u20131.49,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%), hypertension (POR\u2009=\u20091.22, 95% CI 1.02\u20131.44,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200957%), high triglyceride (POR\u2009=\u20091.39, 95% CI 1.06\u20131.83,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%), and metabolic syndrome (PHR\u2009=\u20091.24, 95% CI 1.01\u20131.51,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200924%) were significant risk factors for the development of any precancerous polyp. The association between diabetes and nonalcoholic fatty liver disease and overall precancerous polyps was inconsistent. General obesity (PHR\u2009=\u20093.04, 95% CI 2.01\u20134.60,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%) but not diabetes (PHR\u2009=\u20091.07, 95% CI 0.72\u20131.57,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%) was significantly associated with the risk of advanced precancerous polyps.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Metabolic factors should be considered when recommending surveillance colonoscopy intervals, which in most guidelines are mainly determined based on the findings at colonoscopy, the significance of family history of CRC and genetic predispositions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/obr.70086","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T07:40:11Z","timestamp":1768549211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Metabolic Factors on the Risk of Colorectal Precancerous Polyps Among Individuals at Above\u2010Average Risk for Colorectal Cancer: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2622-522X","authenticated-orcid":false,"given":"Meseret\u00a0Derbew","family":"Molla","sequence":"first","affiliation":[{"name":"Flinders Health and Medical Research Institute, College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"},{"name":"Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molla\u00a0M.","family":"Wassie","sequence":"additional","affiliation":[{"name":"Flinders Health and Medical Research Institute, College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2451-0358","authenticated-orcid":false,"given":"Erin\u00a0L.","family":"Symonds","sequence":"additional","affiliation":[{"name":"Flinders Health and Medical Research Institute, College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"},{"name":"Gastroenterology Department Flinders Medical Centre, Southern Adelaide Local Health Network  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zegeye","family":"Abebe","sequence":"additional","affiliation":[{"name":"Flinders Health and Medical Research Institute, College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"},{"name":"Department of Nutrition, Institute of Public Health, College of Medicine and Health Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u00a0M.","family":"Winter","sequence":"additional","affiliation":[{"name":"Flinders Health and Medical Research Institute, College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.5114\/pg.2018.81072"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529309103127"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.12.066"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1584091"},{"key":"e_1_2_12_7_1","unstructured":"Health AIo Welfare \u201cNational Bowel Cancer Screening Program Monitoring Report 2007 \u201d (2008)."},{"key":"e_1_2_12_8_1","unstructured":"Cancer Council Australia Surveillance Colonoscopy Guidelines Working Party \u201cClinical Practice Guidelines for Surveillance Colonoscopy. 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