{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T14:35:50Z","timestamp":1794407750783,"version":"4.9.0"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The pancreas is a key metabolic organ, and excessive intrapancreatic fat deposition (IPFD) has been implicated in the pathogenesis of Type 2 diabetes. Although IPFD is believed to be reversible, it remains unclear whether glucose\u2010lowering medications can reduce it. This study aimed to perform a field\u2010wide systematic review of randomized controlled trials (RCTs) investigating the effects of such medications on IPFD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three electronic databases\u2014MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials\u2014were searched. RCTs comparing the effects of pharmacological interventions with standard care or placebo on IPFD were meta\u2010analyzed using a random\u2010effects model. The mean difference in IPFD, with its corresponding 95% confidence interval, served as the primary effect estimate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight RCTs met the eligibility criteria, five of which were placebo\u2010controlled. In the overall analysis, glucose\u2010lowering medications were associated with a significant reduction in IPFD (mean difference\u2009=\u2009\u22121.5; 95% CI: \u22121.8, \u22121.1;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Constraining the analysis to placebo\u2010controlled RCTs yielded a larger effect size (mean difference\u2009=\u2009\u22121.8; 95% CI: \u22123.1, \u22120.5;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Among the medication classes meta\u2010analyzed, significant reductions in IPFD were observed with GLP\u20101 receptor agonists (mean difference\u2009=\u2009\u22121.6; 95% CI: \u22122.5, \u22120.7;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and SGLT\u20102 inhibitors (mean difference\u2009=\u2009\u22121.4; 95% CI: \u22121.6, \u22121.1;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Glucose\u2010lowering medications have the potential to reduce IPFD. Rigorously designed RCTs are warranted to confirm the responsiveness of IPFD to pharmacological interventions and to guide their clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/obr.70087","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T05:35:50Z","timestamp":1770010550000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of Glucose\u2010Lowering Medications on Intrapancreatic Fat Deposition: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","volume":"27","author":[{"given":"Harsen\u00a0C.","family":"Agon","sequence":"first","affiliation":[{"name":"School of Medicine University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Medicine University of Auckland  Auckland New Zealand"},{"name":"School of Pharmacy and Bioengineering Chongqing University of Technology  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5923-9062","authenticated-orcid":false,"given":"Maxim\u00a0S.","family":"Petrov","sequence":"additional","affiliation":[{"name":"School of Medicine University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010021\u201000551\u20100"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S400276"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15698"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(23)00064\u2010X"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.24154"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15990"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15550"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13914"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.1523"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010022\u201005793\u20104"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003799"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(16)30004\u20108"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000251"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010024\u201002022\u20107"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj\u20102018\u2010135967"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011640.pub2"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_10_19_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.5","author":"Higgins J. 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