{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T03:58:37Z","timestamp":1780891117749,"version":"3.54.1"},"reference-count":52,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      This systematic review and meta\u2010analysis of randomized controlled trials (RCTs) was conducted to assess the effect of nutraceuticals containing\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Citrus bergamia<\/jats:italic>\n                      <\/jats:styled-content>\n                      on the management of obesity in adults by assessing measures related to obesity. We searched the following databases until October 2024: PubMed, Web of Science, Scopus, and the Cochrane Central Register of Controlled Trials. The inclusion criteria were RCTs involving adults (\u2265\u200918\u2009years), the use of nutraceuticals containing\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>C.\u2009bergamia<\/jats:italic>\n                      <\/jats:styled-content>\n                      , and an intervention duration of \u2265\u20094\u2009weeks. Data extraction focused on weight loss, body mass index, waist circumference, waist\u2010to\u2010hip ratio, and body fat percentage, and the risk of bias was assessed using the Revised Cochrane Risk\u2010of\u2010Bias Tool. Out of 966 reports, 11 RCTs were eligible for inclusion in the meta\u2010analysis. The pooled results, using a random\u2010effects model, showed that\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>C.\u2009bergamia<\/jats:italic>\n                      <\/jats:styled-content>\n                      supplementation significantly decreased body weight (SMD: \u22120.64; 95% CI: \u22121.15, \u22120.13;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200990%), body mass index (SMD: \u22120.85; 95% CI: \u22121.35, \u22120.35;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0008;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200990%), and waist circumference (SMD: \u22120.41; 95% CI: \u22120.65, \u22120.16;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200949%). However, no significant effect of bergamot\u2010containing nutraceuticals was observed on the other body composition parameters analyzed. Subgroup analysis suggested that bergamot intake significantly changed anthropometric parameters for periods of \u2264\u200912\u2009weeks, at dosages of \u2264\u2009600\u2009mg\/day, and among participants with overweight and obesity. Overall, the current meta\u2010analysis suggests that nutraceuticals containing\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>C.\u2009bergamia<\/jats:italic>\n                      <\/jats:styled-content>\n                      show promise in the prevention and management of obesity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration:<\/jats:title>\n                    <jats:p>\n                      International Prospective Register of Systematic Reviews (PROSPERO): CRD42023465541 (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?RecordID=465541\">https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?RecordID=465541<\/jats:ext-link>\n                      )\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/obr.70094","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T05:41:34Z","timestamp":1769146894000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of\n                    <scp>\n                      <i>Citrus bergamia<\/i>\n                    <\/scp>\n                    Supplementation on Body Composition in Humans: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","volume":"27","author":[{"given":"Carmelo","family":"Pujia","sequence":"first","affiliation":[{"name":"O.U. Clinical Nutrition Renato Dulbecco Hospital  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvelise","family":"Ferro","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University \u201cMagna Gr\u00e6cia\u201d of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Castagna","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University \u201cMagna Gr\u00e6cia\u201d of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3198-7090","authenticated-orcid":false,"given":"Elisa","family":"Mazza","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University \u201cMagna Gr\u00e6cia\u201d of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7644-1337","authenticated-orcid":false,"given":"Samantha","family":"Maurotti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University \u201cMagna Gr\u00e6cia\u201d of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca\u00a0Rita","family":"Noto","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University \u201cMagna Gr\u00e6cia\u201d of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University \u201cMagna Gr\u00e6cia\u201d of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Montalcini","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University \u201cMagna Gr\u00e6cia\u201d of Catanzaro  Catanzaro Italy"},{"name":"Research Center for the Prevention and Treatment of Metabolic Diseases University \u201cMagna Gr\u00e6cia\u201d  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Pujia","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University \u201cMagna Gr\u00e6cia\u201d of Catanzaro  Catanzaro Italy"},{"name":"Research Center for the Prevention and Treatment of Metabolic Diseases University \u201cMagna Gr\u00e6cia\u201d  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.706978"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02750-2"},{"key":"e_1_2_9_4_1","unstructured":"T.Lobstein R.Jackson\u2010Leach J.Powis andH.Brinsden \u201cWorld Obesity Atlas 2023 Report (1) \u201d (2023)."},{"key":"e_1_2_9_5_1","unstructured":"Anonymous \u201cSovrappeso e Obesit\u00e0 Dati Sorveglianza Passi \u201d (n.d.)."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15183893"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10198-021-01358-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21358"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442721"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2015.10.031"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/74.5.579"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052671"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28186604"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods13213422"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051504"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.903"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-019-1061-0"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2016.10.008"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.03.008"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_21_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.5","author":"Higgins J. 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