{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:05:59Z","timestamp":1788537959439,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pharmacotherapy offers a potential solution for individuals with overweight and obesity to decrease their body weight. However, there is limited knowledge of the effects of antiobesity agents on the distribution of body fat.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The PubMed, Embase, and Cochrane Library databases were reviewed for randomized controlled trials (RCTs) of weight\u2010lowering drugs between inception and May 23, 2023. The main results were visceral and subcutaneous adipose tissue (VAT and SAT). Secondary outcomes were altered body weights and waist circumferences. For the statistical analysis, STATA 14.0 was utilized, and the frequentist method was used for random\u2010effect network meta\u2010analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 39 articles including 41 RCTs with 2741 patients were included. GLP\u20101 receptor agonists and SGLT\u20102 inhibitors were observed to lower VAT (\u22120.90 [\u22121.32 to \u22120.47] and \u22120.66 [\u22121.22 to \u22120.10]) after a mean of 29.4\u2009weeks, whereas only GLP\u20101 receptor agonists reduced SAT (\u22121.01 [\u22121.58 to \u22120.43]). Naltrexone\u2010bupropion, GLP\u20101 receptor agonists, SGLT\u20102 inhibitors, and metformin were found to reduce body weight (\u22125.60 [\u22128.64 to \u22122.56] kg, \u22124.73 [\u22125.58 to \u22123.88] kg, \u22123.20 [\u22124.69 to \u22121.72] kg, and \u22121.93 [\u22123.01 to \u22120.85] kg). Lastly, waist circumference was decreased by GLP\u20101 receptor agonists, metformin, SGLT\u20102 inhibitors, and naltrexone\u2013bupropion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This analysis demonstrated that GLP\u20101 receptor agonists may have advantages over other antiobesity agents in reducing VAT and SAT. SGLT\u20102 inhibitors were more helpful to reduce VAT. The clinical significance relates to physicians being able to choose appropriate weight\u2010loss agents in accordance with a patient's fat distribution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/obr.70100","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T02:19:46Z","timestamp":1768875586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of Weight\u2010Lowering Agents on Fat Distribution: A Systematic Review and Network Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0816-0078","authenticated-orcid":false,"given":"Xiuqi","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine Chinese Academy of Medical Sciences  Beijing China"},{"name":"Peking Union 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