{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:09:47Z","timestamp":1788862187025,"version":"build-2803163510"},"reference-count":144,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Aim<\/jats:title>\n                    <jats:p>We conducted a systematic review with network meta\u2010analyses (NMA) summarizing the effects and safety of lifestyle interventions containing nutrition (NUT; e.g., calorie restriction), exercise (EX; e.g., aerobic\/resistance exercise) and behavior change interventions (BCI; e.g., behavioral therapy) on physical function, body composition, quality of life, psychosocial outcomes, health and adverse events in community\u2010dwelling older adults with obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used the methodology proposed by Cochrane and searched six databases and one trial registry for eligible randomized controlled trials (RCTs; intervention duration \u2265\u200912\u2009weeks) up to May 2022 with a full new search in MEDLINE and a re\u2010assessment of previously identified eligible trial registry entries in October 2025. Random\u2010effects NMA ((standardized) mean difference ((S)MD), 95% confidence intervals) were conducted if possible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 72 RCTs (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096716) for descriptive summaries and 54 RCTs (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094249) for NMA. NUT+EX+BCI improved physical function (performance batteries) compared to control (SMD 3.37 [1.76;4.97]; high certainty of evidence). NUT+EX+BCI may reduce body (MD \u22128.69 [\u221213.14;\u22124.25]) and fat mass (MD \u22126.58 [\u221210.44;\u22122.73]) while not negatively affecting fat\u2010free mass (MD \u22121.38 [\u22123.52;0.76]) or bone mineral density (MD \u22120.01 [\u22120.05;0.02]) (evidence very uncertain). Other interventions (single\/combined) may also be effective; however, effects were often imprecise. For psychosocial outcomes, quality of life, and health events, data were insufficient or too heterogeneous to derive clear results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The evidence suggests that NUT+EX+BCI interventions are most suitable for the management of obesity in older adults. Nevertheless, further RCTs\u2014especially in frail populations and on patient\u2010relevant outcomes\u2014are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/obr.70123","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:05:00Z","timestamp":1775279100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["EffectS of Lifestyle Interventions in Older PEople With Obesity (Effective SLOPE): a Systematic Review With Network Meta\u2010Analyses"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1463-3119","authenticated-orcid":false,"given":"Gabriel","family":"Torbahn","sequence":"first","affiliation":[{"name":"Institute for Biomedicine of Aging Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Nuremberg Germany"},{"name":"Department of Pediatrics Paracelsus Medical University  Nuremberg 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