{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:09:47Z","timestamp":1788862187055,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Many survivors of childhood brain tumors face long\u2010term adverse health outcomes like obesity. Uncertainties surround the effect of interventions to manage obesity\u2010related outcomes in survivors of childhood brain tumors. The goal of this updated systematic review and meta\u2010analysis was to provide the best estimate of the treatment efficacy of pharmacotherapy intervention on anthropometric outcomes in this pediatric population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We searched CENTRAL, MEDLINE, EMBASE, CINAHL, PsycINFO, PubMed,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      , and ProQuest for articles published from January 1, 2015, to January 31, 2025. A meta\u2010analysis was performed using the generic inverse\u2010variance method in RevMan 5.4. Heterogeneity was assessed using the Cochrane Q test and the I\n                      <jats:sup>2<\/jats:sup>\n                      statistic. We used the GRADE approach to determine the certainty of evidence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of six studies met the inclusion criteria: four newly identified studies published after January 1, 2015 (125 participants), and two from the previously published review (23 participants). The pooled estimate showed no significant change in body mass index z\u2010score after intervention (mean difference\u2009=\u2009\u22120.02; 95% CI: \u22120.06 to 0.02, I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%; 4 studies, 94 participants; low certainty of evidence). Similar pooled effects were observed across other outcomes; however, individual studies reported significant changes in some outcomes within the treatment groups after the intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pharmacological agents showed no significant change in anthropometric outcomes for survivors of childhood brain tumors. Further trials are needed to assess the efficacy of pharmacological agents and to identify subgroups most likely to benefit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/obr.70126","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:51:51Z","timestamp":1775029911000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Efficacy of Pharmacotherapy Intervention on Anthropometric Outcomes in Survivors of Childhood Brain Tumors: An Updated Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"27","author":[{"given":"David","family":"Hart","sequence":"first","affiliation":[{"name":"Mary Heersink School of Global Health and Social Medicine McMaster University  Hamilton Ontario 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