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We conducted a systematic review and meta\u2010analysis to assess if pre\u2010arthroplasty weight loss mitigates increased post\u2010operative risks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This systematic review and meta\u2010analysis was registered on PROSPERO (CRD42023431110). Key terms were utilized to search PubMed, EMBASE, Ovid, Web of Science, Google Scholar, and Europe PMC. Peer\u2010reviewed articles published between January 1, 2010, and December 31, 2024, were screened. Studies that reported specific outcomes (superficial wound infection, deep wound infection, pulmonary embolus [PE], deep vein thrombosis [DVT], and revision surgery) in an intervention group (patients with a BMI\u2009&gt;\u200930\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      who underwent pre\u2010arthroplasty weight loss) and a control group (patients who underwent arthroplasty without preceding weight loss) 90\u2009days post\u2010arthroplasty were selected and data were extracted from studies meeting these inclusion criteria. Data were analyzed using a random effects model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010one articles were included in the meta\u2010analysis. In people with obesity, pre\u2010arthroplasty weight loss was associated with an increased risk of revision surgery in the first 90\u2009days following lower limb arthroplasty (OR 1.37 [1.01\u20131.84],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). Weight loss did not alter the risk of post\u2010operative DVT, PE, superficial wound infections, and deep wound infections.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results demonstrate that pre\u2010arthroplasty weight loss does not improve short\u2010term post\u2010operative outcomes in people with obesity. Large, well\u2010designed prospective studies should be performed to provide robust data for the development of evidence\u2010based guidelines for lower limb arthroplasty in people living with obesity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/obr.70160","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:45:42Z","timestamp":1778651142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations Between Weight Loss Prior to Knee and Hip Arthroplasty and Peri\u2010 and Post\u2010Operative Outcomes: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","author":[{"given":"Moneet","family":"Gill","sequence":"first","affiliation":[{"name":"MSK Lab, Department of Surgery and Cancer Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Lindsay","sequence":"additional","affiliation":[{"name":"MSK Lab, Department of Surgery and Cancer Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0755-1609","authenticated-orcid":false,"given":"Daniel Kevin","family":"Llanera","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Imperial College Healthcare NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5873-3432","authenticated-orcid":false,"given":"Tricia M.\u2010M.","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Imperial College Healthcare NHS Trust  London UK"},{"name":"Section of Investigative Medicine and Endocrinology, Department of Metabolism, Digestion and Metabolism Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Liddle","sequence":"additional","affiliation":[{"name":"MSK Lab, Department of Surgery and Cancer Imperial College London  London UK"},{"name":"Department of Orthopaedic Surgery Imperial College Healthcare NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7599-0166","authenticated-orcid":false,"given":"Chioma","family":"Izzi\u2010Engbeaya","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Imperial College Healthcare NHS Trust  London UK"},{"name":"Section of Investigative Medicine and Endocrinology, Department of Metabolism, Digestion and Metabolism Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Organisation WH \u201cObesity and Overweight \u201d (2021) https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/obesity\u2010and\u2010overweight."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2021.05.022"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u2010789X.2004.00144.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13560"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2019.10.007"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.115"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2016.04.006"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2018.10.002"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.224"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787\u2010011\u20100118\u20100"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39707"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42836\u2010023\u201000203\u20105"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003704"},{"key":"e_1_2_12_15_1","unstructured":"Association AO \u201cNATIONAL JOINT REPLACEMENT REGISTRY: Hip Knee & Shoulder Arthroplasty\u2014Annual Report 2016 \u201d (2016)."},{"key":"e_1_2_12_16_1","unstructured":"Excellence NIfHaC. 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