{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:16:47Z","timestamp":1778894207296,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dumping syndrome and reactive hypoglycemia are common complications after bariatric surgery, particularly Roux\u2010en\u2010Y gastric bypass (RYGB). Semaglutide, a glucagon\u2010like peptide\u20101 (GLP\u20101) receptor agonist, has emerged as a potential therapeutic option, but evidence regarding its efficacy remains scattered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to systematically evaluate the effects of semaglutide on dumping syndrome symptoms and reactive hypoglycemia in post\u2010bariatric surgery patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systematic review and meta\u2010analysis following PRISMA 2020 guidelines. PubMed, Embase, Cochrane Library, and Web of Science were searched from inception to September 2025. Randomized controlled trials and observational studies evaluating semaglutide in post\u2010bariatric surgery patients with dumping syndrome or reactive hypoglycemia were included. Primary outcomes were changes in dumping symptom scores and hypoglycemic episode frequency. Random\u2010effects meta\u2010analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven studies (three RCTs, three cohort studies, one case series) with 337 patients were included. Semaglutide significantly improved dumping symptom scores (standardized mean difference [SMD] \u22121.18; 95% CI \u22121.64 to \u22120.72;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200939%) and reduced hypoglycemic episodes (SMD \u22120.85; 95% CI \u22121.22 to \u22120.48;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200935%). Quality of life improved significantly (SMD 0.73; 95% CI 0.38\u20131.08;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Glycemic variability decreased (SMD \u22120.71; 95% CI \u22121.08 to \u22120.34;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), as did time in hypoglycemia (SMD \u22120.62; 95% CI \u22120.95 to \u22120.29;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Gastrointestinal adverse events were common but rarely led to treatment discontinuation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Semaglutide demonstrates significant efficacy in improving dumping syndrome symptoms and reactive hypoglycemia after bariatric surgery, with an acceptable safety profile. These findings support its consideration as a therapeutic option for these challenging post\u2010bariatric complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/obr.70161","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:59:51Z","timestamp":1778893191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Semaglutide on Dumping Syndrome and Reactive Hypoglycemia After Bariatric Surgery: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2963-7259","authenticated-orcid":false,"given":"Naseem","family":"Eisa","sequence":"first","affiliation":[{"name":"Community Health Partners  Fresno California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Barood","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Damascus University  Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"issue":"9","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1001\/jama.2020.12567","article-title":"Benefits and Risks of Bariatric Surgery in Adults: A Review","volume":"324","author":"Arterburn D. E.","year":"2020","journal-title":"Journal of the American Medical Association"},{"issue":"8","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1056\/NEJMoa066254","article-title":"Effects of Bariatric Surgery on Mortality in Swedish Obese Subjects","volume":"357","author":"Sj\u00f6str\u00f6m L.","year":"2007","journal-title":"New England Journal of Medicine"},{"issue":"10","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nrgastro.2009.148","article-title":"Pathophysiology, Diagnosis and Management of Postoperative Dumping Syndrome","volume":"6","author":"Tack J.","year":"2009","journal-title":"Nature Reviews. Gastroenterology & Hepatology"},{"issue":"11","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1007\/s00125-010-1798-5","article-title":"Nationwide Cohort Study of Post\u2010Gastric Bypass Hypoglycaemia Including 5,040 Patients Undergoing Surgery for Obesity in 1986\u20132006 in Sweden","volume":"53","author":"Marsk R.","year":"2010","journal-title":"Diabetologia"},{"issue":"5","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1007\/s00464-012-2629-1","article-title":"The Role of Dumping Syndrome in Weight Loss After Gastric Bypass Surgery","volume":"27","author":"Banerjee A.","year":"2013","journal-title":"Surgical Endoscopy"},{"issue":"3","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.soard.2014.11.003","article-title":"Hypoglycemia After Roux\u2010en\u2010Y Gastric Bypass: Detection Rates of Continuous Glucose Monitoring (CGM) Versus Mixed Meal Test","volume":"11","author":"Kefurt R.","year":"2015","journal-title":"Surgery for Obesity and Related Diseases"},{"issue":"5","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1177\/0115426505020005517","article-title":"Dumping Syndrome: Pathophysiology and Treatment","volume":"20","author":"Ukleja A.","year":"2005","journal-title":"Nutrition in Clinical Practice"},{"key":"e_1_2_10_9_1","first-page":"21","article-title":"The Dumping Syndrome. Current Insights Into Pathophysiology, Diagnosis and Treatment","volume":"223","author":"Vecht J.","year":"1997","journal-title":"Scandinavian Journal of Gastroenterology. Supplement"},{"issue":"7","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.2337\/dc06-1549","article-title":"Incretin Levels and Effect Are Markedly Enhanced 1 Month After Roux\u2010en\u2010Y Gastric Bypass Surgery in Obese Patients With Type 2 Diabetes","volume":"30","author":"Laferr\u00e8re B.","year":"2007","journal-title":"Diabetes Care"},{"issue":"5","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1097\/SLA.0b013e3180caa3e3","article-title":"Gut Hormones as Mediators of Appetite and Weight Loss After Roux\u2010en\u2010Y Gastric Bypass","volume":"246","author":"Roux C. W.","year":"2007","journal-title":"Annals of Surgery"},{"issue":"9","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.2337\/db11-0203","article-title":"Gastric Bypass Surgery Enhances Glucagon\u2010Like Peptide 1\u2010Stimulated Postprandial Insulin Secretion in Humans","volume":"60","author":"Salehi M.","year":"2011","journal-title":"Diabetes"},{"issue":"4","key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.cmet.2018.03.001","article-title":"Mechanisms of Action and Therapeutic Application of Glucagon\u2010Like Peptide\u20101","volume":"27","author":"Drucker D. J.","year":"2018","journal-title":"Cell Metabolism"},{"issue":"4","key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1152\/physrev.00034.2006","article-title":"The Physiology of Glucagon\u2010Like Peptide 1","volume":"87","author":"Holst J. 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P.","year":"2012","journal-title":"Obesity Surgery"},{"issue":"9","key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1007\/s11695-009-9888-5","article-title":"Successful Medical Management of Status Post\u2010Roux\u2010en\u2010Y\u2010Gastric\u2010Bypass Hyperinsulinemic Hypoglycemia","volume":"19","author":"Spanakis E.","year":"2009","journal-title":"Obesity Surgery"},{"issue":"5","key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1530\/EJE-11-1065","article-title":"Prolonged Successful Therapy for Hyperinsulinaemic Hypoglycaemia After Gastric Bypass: The Pathophysiological Role of GLP\u20101 and Its Response to a Somatostatin Analogue","volume":"166","author":"Myint K. 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M.","year":"2017","journal-title":"Diabetologia"},{"issue":"8","key":"e_1_2_10_26_1","first-page":"645","article-title":"Efficacy of Exenatide on Glucose Control and Hypoglycemic Episodes in Patients With Dumping Syndrome and Reactive Hypoglycemia Secondary to Previous Bariatric Surgery: A Pilot Study","volume":"30","author":"Abramo A.","year":"2014","journal-title":"Diabetes\/Metabolism Research and Reviews"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page M. J.","year":"2021","journal-title":"BMJ"}],"container-title":["Obesity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/obr.70161","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/obr.70161","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/obr.70161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:59:54Z","timestamp":1778893194000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/obr.70161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,15]]},"references-count":26,"alternative-id":["10.1111\/obr.70161"],"URL":"https:\/\/doi.org\/10.1111\/obr.70161","archive":["Portico"],"relation":{},"ISSN":["1467-7881","1467-789X"],"issn-type":[{"value":"1467-7881","type":"print"},{"value":"1467-789X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,15]]},"assertion":[{"value":"2025-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70161"}}