{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:13:07Z","timestamp":1788909187160,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obesity links to adverse cardiovascular outcomes, but subclinical cardiac remodeling patterns remain incompletely characterized. Cardiac magnetic resonance (CMR) provides reproducible assessments of myocardial structure, function, tissue characterization, and adiposity. We conducted a systematic review and meta\u2010analysis to define the obesity\u2010related CMR phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, MEDLINE, EMBASE, Cochrane, Web of Science, and Scopus were searched (2000\u20132025) for studies comparing CMR\u2010derived cardiac parameters in adults with obesity (WHO criteria) versus controls without obesity. Standardized mean differences (SMDs) were pooled using random\u2010effects meta\u2010analysis. Sensitivity analyses and meta\u2010regression explored heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty studies (1395 individuals with obesity, 1260 controls) were included. Obesity was associated with increased epicardial fat volume (SMD 0.74, 95% CI 0.46\u20131.01;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), higher left ventricular mass\/end\u2010diastolic volume ratio (SMD 0.51, 95% CI 0.27\u20130.75;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), increased left ventricular mass index (SMD 0.33, 95% CI 0.13\u20130.53;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), and higher stroke volume (SMD 0.40, 95% CI 0.20\u20130.61;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Despite preserved left ventricular ejection fraction, global longitudinal strain (GLS) was impaired (SMD \u20130.44, 95% CI \u20130.67 to \u22120.20;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), indicating subclinical systolic dysfunction. Sensitivity analyses excluding cohorts with cardiometabolic disease demonstrated consistent findings. Meta\u2010regression identified body mass index as a modifier of GLS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), whereas age influenced left ventricular mass remodeling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Obesity is characterized by a distinct CMR phenotype of concentric ventricular remodeling, excess epicardial adiposity, increased hemodynamic adaptation, and early subclinical myocardial dysfunction despite preserved ejection fraction. These findings highlight potentially reversible early cardiac adaptations contributing to the excess cardiovascular risk associated with obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Registration number: PROSPERO CRD420251083324<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/obr.70194","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:00:17Z","timestamp":1784005217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cardiac Remodeling and Dysfunction Associated in Populations With Obesity: An Analysis of Cardiac Structure and Function"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6741-1096","authenticated-orcid":false,"given":"Shaun","family":"Khanna","sequence":"first","affiliation":[{"name":"The George Institute for Global Health UNSW Sydney  Kensington NSW Australia"},{"name":"Baker Heart and Diabetes Institute  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Wilson","sequence":"additional","affiliation":[{"name":"Western Sydney University  Parramatta NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurkeerat","family":"Mann","sequence":"additional","affiliation":[{"name":"Western Sydney University  Parramatta NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohaib","family":"Virk","sequence":"additional","affiliation":[{"name":"University of Melbourne  Parkville VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Bhat","sequence":"additional","affiliation":[{"name":"Western Sydney University  Parramatta NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Playford","sequence":"additional","affiliation":[{"name":"Institute for Health Research University of Notre Dame Australia  Fremantle WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0939-5470","authenticated-orcid":false,"given":"Faraz","family":"Pathan","sequence":"additional","affiliation":[{"name":"Sydney Medical School Nepean, Charles Perkins Centre  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J. W.","family":"Chow","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Ottawa Heart Institute  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Arnott","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health UNSW Sydney  Kensington NSW Australia"},{"name":"Department of Cardiology St Vincent's Hospital  Darlinghurst NSW Australia"},{"name":"Department of Cardiology Royal Prince Alfred Hospital  Camperdown NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3437-8648","authenticated-orcid":false,"given":"Nitesh","family":"Nerlekar","sequence":"additional","affiliation":[{"name":"Baker Heart and Diabetes Institute  Melbourne VIC Australia"},{"name":"Victorian Heart Hospital, Victorian Heart Institute  Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"3","volume-title":"Handbook of Experimental Pharmacology","author":"S\u00f8rensen T. 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