{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:25:08Z","timestamp":1793053508157,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Obesity is a chronic disease associated with substantial cardiometabolic, mechanical, and psychosocial burden, contributing significantly to global morbidity and mortality. Despite its impact, therapeutic strategies remain disproportionately conservative, often delaying effective intervention. In contrast, treatment algorithms for other chronic diseases, such as type 2 diabetes and rheumatoid arthritis, have adopted remission\u2010oriented approaches aimed at suppressing disease activity rather than merely attenuating progression. In this context, we propose a remission\u2010oriented paradigm for obesity. Remission is defined as a sustained, multidimensional state characterized by the achievement of clinically meaningful adiposity targets, alleviation of obesity\u2010related complications, restoration of functional capacity, and improvement in psychological well\u2010being. Importantly, remission is conceptualized as a continuum, analogous to glycemic states, and may be maintained with ongoing pharmacotherapy. We further propose an induction\u2013remission\u2013maintenance model that prioritizes early, effective intervention. This framework explicitly acknowledges the chronic nature of the disease of obesity, even in the presence of potent therapies, underscoring the need for ongoing monitoring and long\u2010term disease surveillance. Despite challenges related to access, cost, and long\u2010term adherence, this approach offers a structured, disease\u2010centered model with the potential to improve clinical outcomes and reduce healthcare burden.<\/jats:p>","DOI":"10.1111\/obr.70197","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:50:32Z","timestamp":1784015432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Obesity Remission: A Missing Target in Contemporary Medicine"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5853-1352","authenticated-orcid":false,"given":"Theocharis","family":"Koufakis","sequence":"first","affiliation":[{"name":"Second Propaedeutic Department of Internal Medicine, Medical School Aristotle University of Thessaloniki, Hippokration General Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5491-2545","authenticated-orcid":false,"given":"Alexander","family":"Kokkinos","sequence":"additional","affiliation":[{"name":"First Department of Propaedeutic Internal Medicine and Diabetes Center, Medical School National and Kapodistrian University of Athens, Laiko General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4883-8980","authenticated-orcid":false,"given":"Luca","family":"Busetto","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5521-5445","authenticated-orcid":false,"given":"Carel\u00a0W.","family":"le Roux","sequence":"additional","affiliation":[{"name":"School of Medicine University College Dublin  Dublin 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