{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:08:06Z","timestamp":1788851286675,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Healthcare systems face increasing demands in chronic disease management such as obesity. Mobile applications offer scalable tools for weight management, ranging from simple trackers to prescribable digital therapeutics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This review evaluates the effectiveness of fully remote, app\u2010based interventions using a multimodal approach for weight loss in adults with obesity. Complying with international guidelines, these interventions combine behavior change strategies for diet, physical activity, and\/or psychosocial education.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature search was performed. Eligible studies were assessed using the Cochrane Risk of Bias Tool 2 and the Grading of Recommendations, Assessment, Development and Evaluation approach for certainty of evidence. A meta\u2010analysis was performed for body weight outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve randomized controlled trials and five systematic reviews were included, reporting changes in body weight or body mass index. The standardized mean difference of body weight changes at the end of intervention was \u22120.50 (95% confidence interval: \u22120.77, \u22120.22), corresponding to a mean difference of \u22122.61\u2009kg (\u22124.45, \u22120.78). Heterogeneity was substantial (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200979.2%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fully remote, app\u2010based interventions show moderate weight loss with promising potential in obesity management. However, heterogeneity between studies highlights the need for further research into potential factors with a significant influence on the results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/obr.70221","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:24:36Z","timestamp":1788848676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Mobile Application\u2010Based Multimodal Behavioral Interventions on Weight Loss in Obesity: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4867-5885","authenticated-orcid":false,"given":"Emma","family":"Bodner","sequence":"first","affiliation":[{"name":"Sidekick Health Germany GmbH  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0800-9397","authenticated-orcid":false,"given":"Annika","family":"Gentz","sequence":"additional","affiliation":[{"name":"Sidekick Health Germany GmbH  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1910-792X","authenticated-orcid":false,"given":"Kathleen","family":"Wiencke","sequence":"additional","affiliation":[{"name":"Sidekick Health Germany GmbH  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8614-9655","authenticated-orcid":false,"given":"Nora","family":"Mehl","sequence":"additional","affiliation":[{"name":"Sidekick Health Germany GmbH  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3967-5318","authenticated-orcid":false,"given":"Haiko","family":"Schl\u00f6gl","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Nephrology, and Rheumatology University Hospital Leipzig  Leipzig Germany"},{"name":"LeiCeM \u2010 Leipzig Center of Metabolism Leipzig University  Leipzig Germany"},{"name":"Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI\u2010MAG) of the Helmholtz Center Munich at the University of Leipzig and University Hospital Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization \u201cObesity and Overweight \u201d World Health Organization May 7 2025 Accessed May 06 2026 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/obesity\u2010and\u2010overweight."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(14)61748\u20107"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010024\u201003095\u20103"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442721"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25\u2010S008"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0193945919888224"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12071977"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23088"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0022\u20104707.17.07437\u20100"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123634"},{"key":"e_1_2_10_12_1","unstructured":"DSV \u201cBelgium Reimburses Digital Health Application. 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