{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T05:02:59Z","timestamp":1789794179044,"version":"4.0.1"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effects of medium\u2010chain triacylglycerol (MCT) intake on the body composition of individuals with overweight and obesity through a systematic review and meta\u2010analysis of randomized controlled trials (RCTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Cochrane Library, and Embase databases were searched until January 2026. The primary outcome was the change in fat mass (FM) between the MCT intake and control groups; secondary outcomes included body weight (BW), waist circumference (WC), and lean mass (LM). Pooled effect sizes were estimated using random\u2010effects models, and certainty was assessed using GRADE (Grading of Recommendations Assessment, Development and Evaluation). RoB\u20102 was used for assessing risk of bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven RCTs (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009346) were included in this study. MCT intake significantly reduced FM (SMD: \u22120.42; 95% CI: \u22120.67 to \u22120.17), BW (SMD: \u22120.41; 95% CI: \u22120.64 to \u22120.18), and WC (SMD: \u22120.42; 95% CI: \u22120.69 to \u22120.14) compared to controls, with no significant effect on LM. Heterogeneity was low (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%), although the certainty of the evidence was low. Sensitivity analyses for BMI \u2267 25\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      confirmed these findings. Adverse events associated with MCT intake are rare and well\u2010tolerated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MCT intake effectively and safely reduced body fat and waist circumference while preserving lean mass, suggesting its value in obesity management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/obr.70230","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:40:56Z","timestamp":1789792856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Medium Chain Fatty Acids on Body Composition in Individuals with Overweight and Obesity: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0367-7361","authenticated-orcid":false,"given":"Megumi","family":"Minamida","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Kyoto Prefectural University of Medicine, Graduate School of Medical Science  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3209-1790","authenticated-orcid":false,"given":"Hanako","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Kyoto Prefectural University of Medicine, Graduate School of Medical Science  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1707-970X","authenticated-orcid":false,"given":"Hiroshi","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Kyoto Prefectural University of Medicine, Graduate School of Medical Science  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2821-9211","authenticated-orcid":false,"given":"Nozomi","family":"Kuramoto","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Kyoto Prefectural University of Medicine, Graduate School of Medical Science  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Kyoto Prefectural University of Medicine, Graduate School of Medical Science  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8651-4445","authenticated-orcid":false,"given":"Masahide","family":"Hamaguchi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Kyoto Prefectural University of Medicine, Graduate School of Medical Science  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Kyoto Prefectural University of Medicine, Graduate School of Medical Science  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health Effects of Overweight and Obesity in 195 Countries Over 25 Years","volume":"377","author":"GBD 2015 Obesity Collaborators","year":"2015","journal-title":"New England Journal of Medicine"},{"issue":"9669","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0140-6736(09)60318-4","article-title":"Body\u2010Mass Index and Cause\u2010Specific Mortality in 900 000 Adults: Collaborative Analyses of 57 Prospective Studies","volume":"373","author":"Prospective Studies Collaboration","year":"2009","journal-title":"Lancet"},{"issue":"7121","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nature05488","article-title":"Abdominal Obesity and Metabolic Syndrome","volume":"444","author":"Despr\u00e9s J. 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