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While a potential benefit may also be hypothesized in patients with metabolic disorders and malignancy, robust clinical evidence is still lacking. In recent years, attention has turned to their potential impact on cancer risk, although current evidence remains limited and, in some cases, conflicting. Several biological pathways, such as improvements in insulin sensitivity, reductions in chronic inflammation, modulation of cellular signaling, and changes in the tumor microenvironment, have been proposed as possible mechanisms through which GLP\u20101RAs might influence cancer development or progression. However, available data derive from preclinical or observational studies, and high\u2010quality prospective clinical evidence is still lacking. While some reports suggest possible protective associations in specific cancer types, others raise concerns about potential risks, particularly in hormonally sensitive or receptor\u2010expressing tissues. This position paper synthesizes available data on the oncologic safety and potential antitumor effects of GLP\u20101RAs, highlights key knowledge gaps, and discusses clinical implications, underscoring the need for further research to clarify their role in cancer prevention and treatment.<\/jats:p>","DOI":"10.1111\/obr.70231","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:02:50Z","timestamp":1790910170000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incretin\u2010Based Therapy in Patients with Malignancy and Obesity or Type 2 Diabetes. An Italian Association of Medical Oncology (AIOM), Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), Italian Society of Endocrinology (SIE), Italian Society of Pharmacology (SIF), and Italian Society of Obesity (SIO) Position Paper"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9324-3946","authenticated-orcid":false,"given":"Antongiulio","family":"Faggiano","sequence":"first","affiliation":[{"name":"Endocrinology Unit, Department of Clinical &amp; Molecular Medicine, Sant'Andrea University Hospital Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9187-3891","authenticated-orcid":false,"given":"Antonella","family":"Argentiero","sequence":"additional","affiliation":[{"name":"Medical Oncology Department IRCCS Istituto Tumori \u201cGiovanni Paolo II\u201d  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Borghesani","sequence":"additional","affiliation":[{"name":"Section of Innovation Biomedicine\u2010Oncology Area, Department of Engineering for Innovation Medicine University of Verona and Verona University and Hospital Trust (AOUI)  Verona Italy"},{"name":"Medical Oncology Unit IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2319-869X","authenticated-orcid":false,"given":"Jonida","family":"Haxhi","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Department of Clinical &amp; 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