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The disruption of the physiological circadian rhythm leads to metabolic alterations, such as decreased insulin sensitivity, increased adipogenesis, and inflammation, with effects on their health and leading, among other diseases, to obesity. Omics technologies represent novel investigation tools to understand in depth the biological mechanisms behind the circadian disruption and consequent effects on metabolism. The data obtained from the use of omics technologies in the field of transcriptomics, proteomics, metabolomics, and metagenomics reveal the involvement of molecular pathways in the circadian disruption due to shift work and give comprehensive insights into the most crucial molecules, such as clock genes, hormones, or microorganisms responsible for a downstream cascade effect. There is a clear need to further explore obesity risk in night shift workers through omics\u2010based studies, particularly in human field studies. Many of the investigations so far have focused on animal models with simulated circadian disruption. Upcoming omics data can undoubtedly support the advancement toward a personalized approach that could protect the health of night shift workers. This review focuses on studies supported by omics technologies on circadian disruption and metabolic alterations leading to obesity or increasing its risk.<\/jats:p>","DOI":"10.1111\/obr.70233","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:30:13Z","timestamp":1790407813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating Overweight and Obesity Risk in Shift Workers Using Omics Technologies"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3945-9185","authenticated-orcid":false,"given":"Katrin","family":"Scionti","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"V\u00e1clavkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences University of Vienna  Vienna 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