{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:44:49Z","timestamp":1792143889270,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018693","name":"HORIZON EUROPE Framework Programme","doi-asserted-by":"publisher","award":["101080117"],"award-info":[{"award-number":["101080117"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["10093560"],"award-info":[{"award-number":["10093560"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["10106435"],"award-info":[{"award-number":["10106435"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Obesity and overweight pose a global health and economic burden. Lifestyle interventions are recommended as first\u2010line treatment. Given their individual complexity, personalized lifestyle interventions may be more effective than one\u2010size\u2010fits\u2010all approaches. This review assessed the methodology, findings and reporting quality of cost\u2010effectiveness analyses evaluating personalized lifestyle interventions in adults with overweight or obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MEDLINE, Embase, Web of Science, and Scopus were searched in March 2025, with backward reference tracking. Full economic evaluations were included without date restrictions. Studies were categorized by highest applicable personalization level: behavioral (Level 1), phenotype\u2010based (Level 2), or omics\u2010based (Level 3). Reporting quality was assessed using the CHEERS 2022 Checklist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 15,385 records screened, 18 studies were included. Fourteen evaluated Level 1 interventions and two each evaluated Levels 2 and 3. Thirteen were cost\u2010utility analyses: seven reported cost\u2010effective or dominant findings, four reported not cost\u2010effective findings, and two reported unclear or mixed results. Ten studies reported cost\u2010effectiveness using clinical outcomes: eight showed favorable findings for at least one outcome, and two reported unclear findings. Heterogeneity in intervention design and methods between studies precluded robust conclusions. Findings for level 1 were mixed, evidence for levels 2 and 3 was limited, with favorable and inconsistent findings, respectively.\u00a0<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Evidence on the cost\u2010effectiveness of personalized lifestyle interventions was mixed and predominantly behavioral personalization. The scarcity of economic evaluations evaluating more advanced personalized lifestyle interventions remains a key evidence gap. Future research should evaluate their added value to inform resource allocation in obesity management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/obr.70234","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:53:45Z","timestamp":1792140825000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cost\u2010Effectiveness of Personalized Lifestyle Interventions in Adults With Overweight\/Obesity: A Systematic Review"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9786-5319","authenticated-orcid":false,"given":"Delfien","family":"Gryspeerdt","sequence":"first","affiliation":[{"name":"Department of Public Health and Primary Care, Interuniversity Centre for Health Economics Research (I\u2010CHER) Ghent University  Ghent 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