{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:04:26Z","timestamp":1790229866514,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The escalating global prevalence of both obesity and obstructive sleep apnea (OSA) represents a major public health challenge due to their combined impact on individual health outcomes and healthcare infrastructure. This review provides an analytical evaluation of the complex, bidirectional relationship between these conditions. Evidence demonstrates that OSA prevalence rises markedly across progressive body mass index (BMI) categories, reaching up to 90% in individuals with Class III obesity. This association is driven by mechanical mechanisms\u2014such as upper airway pharyngeal fat accumulation and reduced lung volumes\u2014as well as systemic metabolic inflammation and cellular dysfunction. Conversely, OSA promotes weight gain and metabolic dysregulation through sleep fragmentation, excessive daytime somnolence, and disruption of appetite\u2010regulating hormones (elevated ghrelin and leptin resistance). Interventions yielding weight loss, including structured lifestyle modifications, novel glucagon\u2010like peptide\u20101 (GLP\u20101) receptor agonists, and bariatric surgery, demonstrate significant reductions in the apnea\u2013hypopnea index (AHI) and cardiometabolic risk. Given the high co\u2010occurrence and severe cardiovascular risk associated with untreated OSA, routine clinical screening and integrated multidisciplinary management strategies targeting both conditions are essential.<\/jats:p>","DOI":"10.1111\/obr.70235","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:43:33Z","timestamp":1790228613000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Intertwined Epidemics of Obesity and Obstructive Sleep Apnea: A Comprehensive Analysis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0021-4223","authenticated-orcid":false,"given":"Sarang","family":"Patil","sequence":"first","affiliation":[{"name":"Department of Pulmonary, Critical Care and Sleep Medicine Maharashtra University of Health Sciences  Nashik Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"issue":"19","key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel","volume":"285","author":"Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults","year":"2001","journal-title":"Journal of the American Medical Association"},{"key":"e_1_2_13_3_1","first-page":"1","volume-title":"Obesity: Preventing and Managing the Global Epidemic. 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