{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T05:41:29Z","timestamp":1761716489853},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T00:00:00Z","timestamp":1373846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Structured Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To characterize the size and the morphology of the frontal sinus (i.e.<jats:italic>,<\/jats:italic> structure evolved by bone resorption) and the nasal bone (i.e., structure evolved by bone formation) in adults with hypophosphatemic rickets (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) compared with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and sample population<\/jats:title><jats:p>Thirty\u2010six patients with <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> (12 males and 24 females) aged 21\u201374\u00a0years were included. The control group comprised 49 healthy individuals (23 males and 26 females) aged 20\u201379\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Profile cephalograms were obtained and the following measurements were included: height and width of the frontal sinus; length, width, and area of the nasal bone. The morphology of the nasal bone was assessed. Linear regression analyses were used to compare <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> patients with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> patients, the size of the frontal sinus was unaffected (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.406 to <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.862). The proximal width of the nasal bone, and the ratio between the proximal width and the axial length of the nasal bone were increased in <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> patients (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The size of the frontal sinus was unaffected, indicating a normal ability of bone resorption within the bone. The morphology of the nasal bone was abnormal indicating a disturbance in bone formation during growth. The disturbances in nasal bone modeling were mainly expressed in the proximal part supported by structures of cartilaginous origin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12028","type":"journal-article","created":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T05:56:37Z","timestamp":1373867797000},"page":"246-255","source":"Crossref","is-referenced-by-count":6,"title":["Morphological characteristics of frontal sinus and nasal bone focusing on bone resorption and apposition in hypophosphatemic rickets"],"prefix":"10.1111","volume":"16","author":[{"given":"H.","family":"Gj\u00f8rup","sequence":"first","affiliation":[{"name":"Center for Oral Health in Rare Diseases Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Dentistry Faculty of Health Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Department of Orthodontics Institute of Odontology University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Sonnesen","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Department of Orthodontics Institute of Odontology University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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