{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T19:35:28Z","timestamp":1773689728925,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T00:00:00Z","timestamp":1419811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Structured Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the effectiveness of distraction osteogenesis to orthognathic surgery for the treatment of maxillary hypoplasia in individuals with cleft lip and palate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A systematic review of prospective randomized, quasi\u2010randomized or controlled clinical trials. <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content>, Scopus, Web of Science, <jats:styled-content style=\"fixed-case\">CINAHL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CENTRAL<\/jats:styled-content>, trial registers and grey literature were searched. Hand searching of five relevant journals was completed. Two reviewers independently completed inclusion assessment. Data extraction and risk of bias assessment were completed by a single reviewer and checked by a second reviewer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five publications all reporting different outcomes of a single randomized controlled trial are included within the review. The quality of the evidence was low with a high risk of bias. Both surgical interventions produce significant soft tissue improvement. Horizontal relapse of the maxilla was statistically significantly greater following orthognathic surgery. There was no statistically significant difference in speech and velo\u2010pharyngeal function between the interventions. Maxillary distraction initially lowered social self\u2010esteem, but this improved with time resulting in higher satisfaction with life in the long term.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The low quality of evidence included within the review means there is insufficient evidence to conclude whether there is a difference in effectiveness between maxillary distraction and osteotomy for the treatment of cleft\u2010related maxillary hypoplasia. There is a need for further high\u2010quality randomized controlled trials to allow conclusive recommendations to be made.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12063","type":"journal-article","created":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T12:49:05Z","timestamp":1419857345000},"page":"96-108","source":"Crossref","is-referenced-by-count":40,"title":["Distraction osteogenesis versus orthognathic surgery for the treatment of maxillary hypoplasia in cleft lip and palate patients: a systematic review"],"prefix":"10.1111","volume":"18","author":[{"given":"S. L.","family":"Austin","sequence":"first","affiliation":[{"name":"Orthodontic Department Royal Derby Hospital Derby UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. R.","family":"Mattick","sequence":"additional","affiliation":[{"name":"Orthodontic Department Newcastle Dental Hospital Newcastle\u2010upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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