{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:23:42Z","timestamp":1789086222944,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T00:00:00Z","timestamp":1428537600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE024450"],"award-info":[{"award-number":["DE024450"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Structured Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the 3D morphological variations in 169 temporomandibular ioint (<jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>) condyles, using novel imaging statistical modeling approaches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and sample population<\/jats:title><jats:p>The Department of Orthodontics and Pediatric Dentistry at the University of Michigan. Cone beam <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scans were acquired from 69 subjects with long\u2010term <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> osteoarthritis (<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>, mean age 39.1\u00a0\u00b1\u00a015.7\u00a0years), 15 subjects at initial consult diagnosis of <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> (mean age 44.9\u00a0\u00b114.8\u00a0years), and seven healthy controls (mean age 43\u00a0\u00b1\u00a012.4\u00a0years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>3D surface models of the condyles were constructed, and homologous correspondent points on each model were established. The statistical framework included Direction\u2013Projection\u2013Permutation (DiProPerm) for testing statistical significance of the differences between healthy controls and the <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> groups determined by clinical and radiographic diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Condylar morphology in <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> and healthy subjects varied widely with categorization from mild to severe bone degeneration or overgrowth. DiProPerm statistics supported a significant difference between the healthy control group and the initial diagnosis of <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> group (<jats:italic>t<\/jats:italic>\u00a0=\u00a06.6, empirical <jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a00.006) and between healthy and long\u2010term diagnosis of <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> group (<jats:italic>t<\/jats:italic>\u00a0=\u00a07.2, empirical <jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a00). Compared with healthy controls, the average condyle in <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> subjects was significantly smaller in all dimensions, except its anterior surface, even in subjects with initial diagnosis of <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This new statistical modeling of condylar morphology allows the development of more targeted classifications of this condition than previously possible.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12070","type":"journal-article","created":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T00:45:13Z","timestamp":1428713113000},"page":"18-28","source":"Crossref","is-referenced-by-count":17,"title":["3D superimposition and understanding temporomandibular joint arthritis"],"prefix":"10.1111","volume":"18","author":[{"given":"L. H. S.","family":"Cevidanes","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Pediatric Dentistry University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. R.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Pediatric Dentistry University of Michigan Ann Arbor MI USA"},{"name":"Department of Orthodontics and Pediatric Dentistry Universidade Estadual Paulista Araraquara SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. T.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Private Practice Salvador BA Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C. O.","family":"Ruellas","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Pediatric Dentistry University of Michigan Ann Arbor MI USA"},{"name":"Department of Orthodontics Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Goncalves","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Pediatric Dentistry Universidade Estadual Paulista Araraquara SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Schilling","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Styner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kapila","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Pediatric Dentistry University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Paniagua","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.0022-0337.2008.72.8.tb04569.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20124"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204111"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2655"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070109"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.04.014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.04.001"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.02.023"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.11607\/jop.1151"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr\/59263880"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20130273"},{"key":"#cr-split#-e_1_2_9_13_1.1","unstructured":"Slicer.org [homepage on the internet].Boston: Surgical Planning Laboratory Harvard Medical School[updated 2014 Sep 01"},{"key":"#cr-split#-e_1_2_9_13_1.2","unstructured":"cited 2014 Sep 01]. Available:http:\/\/download.slicer.org"},{"key":"e_1_2_9_14_1","unstructured":"Itksnap.org [homepage on the internet].Philapelphia: Penn Image Computing and Science Laboratory University of Pennsylvania; [updated 2014 May 17; cited 2014 Sep 01]. Available:http:\/\/www.itksnap.org"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2010.01.008"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compmedimag.2010.11.012"},{"key":"e_1_2_9_17_1","first-page":"242","article-title":"Framework for the statistical shape analysis of brain structures using SPHARM\u2010PDM","volume":"1071","author":"Styner M","year":"2006","journal-title":"Insight J"},{"key":"#cr-split#-e_1_2_9_18_1.1","unstructured":"Spharm\u2010PDM [homepage on the Internet].Chapel Hill: Neuro Image Research and Analysis Laboratories University of North Carolina [updated 2014 Jul 21"},{"key":"#cr-split#-e_1_2_9_18_1.2","unstructured":"cited 2014 Sep 01]. Available:http:\/\/www.nitrc.org\/projects\/spharm-pdm."},{"key":"#cr-split#-e_1_2_9_19_1.1","unstructured":"Shape Analysis Mancova [homepage on the Internet].Chapel Hill: Neuro Image Research and Analysis Laboratories University of North Carolina [updated 2014 June 27"},{"key":"#cr-split#-e_1_2_9_19_1.2","unstructured":"cited 2014 Sep 01]. Available:http:\/\/www.nitrc.org\/projects\/shape_mancova."},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","unstructured":"PaniaguaB StynerM MacenkoM PantazisD NiethammerM.Local shape analysis using MANCOVA. Insight Journal [serial on the Internet]. 2009 Sep [cited 2014 Sep 15; about 21 p.]. Available:http:\/\/www.insight-journal.org\/browse\/publication\/694.","DOI":"10.54294\/lqfift"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1198\/jasa.2010.tm08487"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2009.01.025"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2839"},{"key":"e_1_2_9_24_1","first-page":"244","article-title":"Osteoarthritis: a tale of three tissues","volume":"66","author":"Samuels J","year":"2008","journal-title":"Bull NYU Hosp Jt Dis"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-010-0943-z"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-010-1001-6"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2008.2004401"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198612000-00005"}],"container-title":["Orthodontics &amp; Craniofacial Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Focr.12070","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ocr.12070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T07:47:27Z","timestamp":1694591247000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ocr.12070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":30,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/ocr.12070"],"URL":"https:\/\/doi.org\/10.1111\/ocr.12070","archive":["Portico"],"relation":{},"ISSN":["1601-6335","1601-6343"],"issn-type":[{"value":"1601-6335","type":"print"},{"value":"1601-6343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}