{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:32:34Z","timestamp":1790616754355,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T00:00:00Z","timestamp":1428537600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006733","name":"Indiana University","doi-asserted-by":"publisher","award":["Bixler Fund for Research in Genetics"],"award-info":[{"award-number":["Bixler Fund for Research in Genetics"]}],"id":[{"id":"10.13039\/100006733","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Southern Association of Orthodontists"},{"name":"University of Kentucky E. Preston Hicks Endowed Chair"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Structured Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>As genetic variation accounts for two\u2010thirds of the variation in external apical root resorption (<jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>) concurrent with orthodontic treatment, we analyzed the association of selected genetic and treatment\u2010related factors with <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content> concurrent with orthodontic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and sample population<\/jats:title><jats:p>This case\u2013control study of 134 unrelated, orthodontically treated Caucasian individuals was conducted in part at an Indiana Private Practice, Indiana University and the University of Kentucky.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Utilizing a research data bank containing information from ~1450 orthodontically treated patients, pre\u2010 and post\u2010treatment radiographs from 460 individuals were evaluated for <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content> of the four permanent maxillary incisors. Sixty\u2010seven unrelated Caucasians with moderate to severe <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content> were identified and were age\u2010\/sex\u2010matched with orthodontically treated Caucasian controls yielding 38 females and 29 males per group. Factors tested for an association with <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content> included the following: 1) treatment duration, 2) extraction of maxillary premolars, 3) numerous cephalometric measurements, and 4) <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> polymorphisms within\/near candidate genes in a pathway previously implicated in <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content> such as the purinergic\u2010receptor\u2010P2X, ligand\u2010gated ion channel 7 (<jats:italic>P2<jats:styled-content style=\"fixed-case\">RX<\/jats:styled-content>7;<\/jats:italic> rs208294, rs1718119, and rs2230912), caspase\u20101 (<jats:italic><jats:styled-content style=\"fixed-case\">CASP<\/jats:styled-content>1<\/jats:italic>; rs530537, rs580253, and rs554344), interleukin\u20101 beta (<jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1B;<\/jats:italic> rs1143634), interleukin\u20101 alpha (<jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1A;<\/jats:italic> rs1800587), and interleukin\u20101 receptor antagonist (<jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content><\/jats:italic>; rs419598) genes. Stepwise logistic regression was utilized to identify the factors significantly associated (significance taken at or less than the layered Bonferroni correction alpha) with the occurrence of <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A long length of treatment and the presence of specific genotypes for <jats:italic>P2<jats:styled-content style=\"fixed-case\">RX<\/jats:styled-content>7 <\/jats:italic><jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> rs208294 were significantly associated with <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content> occurrence was associated with both genetic and treatment\u2010related variables, which together explained 25% of the total variation associated with <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content> in the sample tested.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12078","type":"journal-article","created":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T00:45:13Z","timestamp":1428713113000},"page":"71-82","source":"Crossref","is-referenced-by-count":72,"title":["Genetic and treatment\u2010related risk factors associated with external apical root resorption (<scp>EARR<\/scp>) concurrent with orthodontia"],"prefix":"10.1111","volume":"18","author":[{"given":"L. Y.","family":"Sharab","sequence":"first","affiliation":[{"name":"Department of Oral Health Practice University of Kentucky College of Dentistry Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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