{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:09:13Z","timestamp":1777421353433,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T00:00:00Z","timestamp":1428537600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Structured Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine minimal dose levels required for local inhibition of orthodontic relapse by recombinant <jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content> protein (<jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content>\u2010Fc), while also determining effects of injected <jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content>\u2010Fc on alveolar bone and long bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and Sample Population<\/jats:title><jats:p>The Department of Orthodontics and Pediatric Dentistry at the University of Michigan. Eighteen male Sprague Dawley rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials &amp; Methods<\/jats:title><jats:p>Maxillary molars were moved with nickel\u2013titanium springs and then allowed to relapse in Sprague Dawley rats. Upon appliance removal, animals were injected with a single dose of 1.0\u00a0mg\/kg <jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content>\u2010Fc, 0.1\u00a0mg\/kg <jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content>\u2010Fc, or phosphate\u2010buffered saline (vehicle) just distal to the molar teeth. Tooth movement measurements were made from stone casts, which were scanned and digitally measured. Alveolar tissues were examined by histology. Micro\u2010computed tomography was used to quantify changes in alveolar and femur bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Local injection of <jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content>\u2010Fc inhibited molar but not incisor relapse, when compared to vehicle\u2010injected animals. No significant differences in alveolar or femur bone were seen between the three treatment groups after 24\u00a0days of relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrate that a single local injection of <jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content>\u2010Fc effectively inhibits orthodontic relapse, with minimal systemic bone metabolic effects. Our results also show that a single injection of <jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content>\u2010Fc will influence tooth movement only in teeth close to the injection site. These findings indicate that <jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content>\u2010Fc has potential as a safe and effective pharmacological means to locally control osteoclasts, for uses such as maintaining anchorage during orthodontic tooth movement and preventing orthodontic relapse in humans.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12086","type":"journal-article","created":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T00:45:13Z","timestamp":1428713113000},"page":"187-195","source":"Crossref","is-referenced-by-count":31,"title":["Locally limited inhibition of bone resorption and orthodontic relapse by recombinant osteoprotegerin protein"],"prefix":"10.1111","volume":"18","author":[{"given":"D. A.","family":"Schneider","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Pediatric Dentistry School of Dentistry University of Michigan  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Pediatric Dentistry School of Dentistry University of Michigan  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Pediatric Dentistry School of Dentistry University of Michigan  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Hayami","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Pediatric Dentistry School of Dentistry University of Michigan  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kapila","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Pediatric Dentistry School of Dentistry University of Michigan  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. E.","family":"Hatch","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Pediatric Dentistry School of Dentistry University of Michigan  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080109"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.2.348"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.040305"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809493"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-012-2052-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00256-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(91)90029-I"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345940730081301"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200906"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-6343.2006.00340.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302707"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408301206"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.04.194"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-012-9579-4"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.141"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060252"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(67)90118-2"},{"key":"e_1_2_8_19_1","first-page":"1","article-title":"Summary review of tissue changes incident to tooth movement","volume":"8","author":"Stuteville O","year":"1938","journal-title":"Angle Orthod"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2005.06.005"}],"container-title":["Orthodontics &amp; Craniofacial Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Focr.12086","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ocr.12086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T07:47:14Z","timestamp":1694591234000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ocr.12086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":19,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/ocr.12086"],"URL":"https:\/\/doi.org\/10.1111\/ocr.12086","archive":["Portico"],"relation":{},"ISSN":["1601-6335","1601-6343"],"issn-type":[{"value":"1601-6335","type":"print"},{"value":"1601-6343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}