{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:47:35Z","timestamp":1780480055116,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T00:00:00Z","timestamp":1453248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Science, Sports, and Culture of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Structured Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effects of diabetes on orthodontic tooth movement and orthodontically induced root resorption in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and sample population<\/jats:title><jats:p>Twenty\u2010three 10\u2010week\u2010old male Sprague\u2010Dawley rats divided into control (n = 7), diabetes (n = 9), and diabetes + insulin (n = 7) groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Diabetes was induced by administering a single intraperitoneal injection of streptozotocin. Rats with a blood glucose level exceeding 250 mg\/dl were assigned to the diabetes group. Insulin was administered daily to the diabetes + insulin group. A nickel\u2013titanium closed\u2010coil spring of 10 g was applied for 2 weeks to the maxillary left first molar in all rats to induce mesial tooth movement. Tooth movement was measured using microcomputed tomography images. To determine the quantity of root resorption, the mesial surfaces of the mesial and distal roots of the first molar were analyzed using both scanning electron microscopy and scanning laser microscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 2 weeks, the amount of tooth movement in the diabetic rats was lower than that in the control rats. Root resorption was also significantly lower in the diabetic rats. These responses of the rats caused by diabetes were mostly diminished by insulin administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Diabetes significantly reduced orthodontic tooth movement and orthodontically induced root resorption in rats. The regulation of blood glucose level through insulin administration largely reduced these abnormal responses to orthodontic force application.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12117","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T02:28:48Z","timestamp":1453343328000},"page":"83-92","source":"Crossref","is-referenced-by-count":25,"title":["Effects of diabetes on tooth movement and root resorption after orthodontic force application in rats"],"prefix":"10.1111","volume":"19","author":[{"given":"K.","family":"Arita","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics Graduate School of Biomedical Sciences Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Hotokezaka","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics Graduate School of Biomedical Sciences Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics Graduate School of Biomedical Sciences Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nakano\u2010Tajima","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics Graduate School of Biomedical Sciences Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kurohama","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics Graduate School of Biomedical Sciences Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics Graduate School of Biomedical Sciences Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Darendeliler","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Sydney Dental Hospital, South Western Sydney Area Health Service The University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics Graduate School of Biomedical Sciences Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,20]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization (WHO).World Health Statistics 2012.Geneva:WHO. Available:http:\/\/www.who.int\/gho\/publications\/world_health_statistics\/EN_WHS2012_Full.pdf: 254\u2010263 Accessed 28 September 2014."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.9.1414"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1047"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mod.2003.53"},{"key":"e_1_2_7_6_1","first-page":"34","volume-title":"IDF Diabetes Atlas","author":"International Diabetes Federation","year":"2013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2118"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.39.4.477"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02561404"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/17.3.177"},{"key":"e_1_2_7_12_1","first-page":"1","article-title":"Hisotologocal study of experimental tooth movement in streptozotocin\u2010induced diabetic rats","volume":"52","author":"Kamo N","year":"1993","journal-title":"J Jpn Ortho Soc"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2010.00793.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035980"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2319\/052007-240.1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60484-9"},{"key":"e_1_2_7_17_1","first-page":"362","article-title":"2013 ACCF\/AHA guideline for the management of ST\u2010elevation myocardial infarction: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"127","author":"O'Gara PT","year":"2013","journal-title":"Circulation"},{"key":"e_1_2_7_18_1","first-page":"150","volume-title":"Parathyroid Glands and Metabolic Bone Disease","author":"Albright F","year":"1948"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.49.1"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1239"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1408"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500606"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-123-5-2600"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.20.3.0367"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02164310"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2010.06.021"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2009.0085"}],"container-title":["Orthodontics &amp; Craniofacial Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Focr.12117","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ocr.12117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T13:37:44Z","timestamp":1695735464000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ocr.12117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,20]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/ocr.12117"],"URL":"https:\/\/doi.org\/10.1111\/ocr.12117","archive":["Portico"],"relation":{},"ISSN":["1601-6335","1601-6343"],"issn-type":[{"value":"1601-6335","type":"print"},{"value":"1601-6343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,20]]}}}