{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T22:45:59Z","timestamp":1768689959790,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T00:00:00Z","timestamp":1456185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008364","name":"Tandl\u00e6geforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Structured Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>1) The objective of this study was to explore radiological signs of intracranial and nuchal ligament calcifications in adult patients with X\u2010linked hypophosphatemia (<jats:styled-content style=\"fixed-case\">XLH<\/jats:styled-content>) compared with controls and 2) to correlate signs of cranial calcifications in <jats:styled-content style=\"fixed-case\">XLH<\/jats:styled-content> patients with the presence of other extra\u2010cranial enthesopathies, with the severity of skeletal <jats:styled-content style=\"fixed-case\">XLH<\/jats:styled-content> impact and with medical treatment during childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and Sample Population<\/jats:title><jats:p>Lateral and postero\u2010anterior cephalograms from 36 adult <jats:styled-content style=\"fixed-case\">XLH<\/jats:styled-content> patients and 49 adult controls and X\u2010rays from spine, pelvis, knees and ankles from 31 of the 36 <jats:styled-content style=\"fixed-case\">XLH<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Radiological signs of intracranial and nuchal ligament calcifications in <jats:styled-content style=\"fixed-case\">XLH<\/jats:styled-content> patients were compared with controls by Fischer's exact test. In <jats:styled-content style=\"fixed-case\">XLH<\/jats:styled-content> patients, the presence of cranial calcifications was correlated with the presence of other enthesopathies, with the severity of skeletal <jats:styled-content style=\"fixed-case\">XLH<\/jats:styled-content> impact and with medical treatment by Fischer's exact or chi\u2010squared test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six (17%) <jats:styled-content style=\"fixed-case\">XLH<\/jats:styled-content> patients revealed major signs of intracranial calcifications. Nuchal ligament calcifications were common in <jats:styled-content style=\"fixed-case\">XLH<\/jats:styled-content> patients compared with controls (<jats:italic>p<\/jats:italic> = 0.018). Enthesopathy was present at 0\u201324 sites per <jats:styled-content style=\"fixed-case\">XLH<\/jats:styled-content> patient (median 2). Intracranial calcifications trended to correlate positively with vertebral enthesopathies (<jats:italic>p =<\/jats:italic> 0.059). Nuchal calcifications correlated positively with the severity of skeletal <jats:styled-content style=\"fixed-case\">XLH<\/jats:styled-content> impact (<jats:italic>p<\/jats:italic> = 0.040). Vertebral enthesopathies correlated negatively with medical treatment (<jats:italic>p<\/jats:italic> = 0.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>More <jats:styled-content style=\"fixed-case\">XLH<\/jats:styled-content> patients than controls showed nuchal ligament calcifications, and some <jats:styled-content style=\"fixed-case\">XLH<\/jats:styled-content> patients showed intracranial calcifications. Severely affected <jats:styled-content style=\"fixed-case\">XLH<\/jats:styled-content> patients often had nuchal ligament calcifications. Medically treated <jats:styled-content style=\"fixed-case\">XLH<\/jats:styled-content> patients had few vertebral enthesopathies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12120","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T17:53:12Z","timestamp":1456422792000},"page":"114-125","source":"Crossref","is-referenced-by-count":13,"title":["A radiological study on intra\u2010 and extra\u2010cranial calcifications in adults with X\u2010linked hypophosphatemia and associations with other mineralizing enthesopathies and childhood medical treatment"],"prefix":"10.1111","volume":"19","author":[{"given":"H.","family":"Gj\u00f8rup","sequence":"first","affiliation":[{"name":"Section of Oral Health in Rare Diseases Department of Maxillofacial Surgery Aarhus University Hospital Aarhus Denmark"},{"name":"Section for Paediatric Dentistry Department of Dentistry, Health Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Institute of Odontology Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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