{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:32:39Z","timestamp":1754487159468},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1\u2010NS\u20102\u20102302"],"award-info":[{"award-number":["1\u2010NS\u20102\u20102302"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Structured Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore asymmetry values of antimeric deciduous tooth crown dimensions in three types of twins: monozygotic (<jats:styled-content style=\"fixed-case\">MZ<\/jats:styled-content>), dizygotic same\u2010sex (<jats:styled-content style=\"fixed-case\">DZ<\/jats:styled-content>) and opposite\u2010sex (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) vs. single\u2010born controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and sample population<\/jats:title><jats:p>Mesiodistal and labio\u2010lingual crown dimensions of second deciduous molars and mesiodistal canine and first molar crown dimensions of 2159 children at 6\u201312 years of age were evaluated, originating from the <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> cross\u2010sectional Collaborative Perinatal Study from the 1970s, including altogether <jats:styled-content style=\"fixed-case\">MZ<\/jats:styled-content> (n = 28), <jats:styled-content style=\"fixed-case\">DZ<\/jats:styled-content> same\u2010sex (n = 33) and <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> (n = 39) pairs. Single born (n = 1959) were used as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Dental casts were measured for comparison of variance relationships calculated from antimeric teeth, exhibiting fluctuating (<jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>), and directional (<jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>) asymmetry using <jats:sc>anova<\/jats:sc>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant differences appeared in <jats:styled-content style=\"fixed-case\">MZ<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> girls in <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> of deciduous canines, which gain size in the first and second trimester, and deciduous second molars, which finally stop crown growth during the early post\u2010natal period. Significantly, increased <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content> values appeared for lower deciduous canines and second molars, indicating greatest environmental stress in <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> girls, <jats:styled-content style=\"fixed-case\">MZ<\/jats:styled-content> girls and <jats:styled-content style=\"fixed-case\">DZ<\/jats:styled-content> boys. Twin girls had more fluctuating and directional crown asymmetry than twin boys, but in some dimensions, the twins were more symmetric than controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Transmembrane hormonal influence between opposite\u2010sex twins, and late gestational stress factors, caused by placental malfunction and\/or monochorionicity, may be involved in asymmetric growth of antimers, during critical periods of crown size gain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12122","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T10:34:43Z","timestamp":1456137283000},"page":"145-153","source":"Crossref","is-referenced-by-count":7,"title":["Primary tooth size asymmetry in twins and singletons"],"prefix":"10.1111","volume":"19","author":[{"given":"T.","family":"Heikkinen","sequence":"first","affiliation":[{"name":"Oral Development and Orthodontics Unit of Oral Health Sciences, University of Oulu Oulu Finland"},{"name":"Medical Research Center, Oulu Oulu Finland"},{"name":"Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Harila","sequence":"additional","affiliation":[{"name":"Oral Development and Orthodontics Unit of Oral Health Sciences, University of Oulu Oulu Finland"},{"name":"Medical Research Center, Oulu Oulu Finland"},{"name":"Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ollikkala","sequence":"additional","affiliation":[{"name":"Oral Development and Orthodontics Unit of Oral Health Sciences, University of Oulu Oulu Finland"},{"name":"Medical Research Center, Oulu Oulu Finland"},{"name":"Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Alvesalo","sequence":"additional","affiliation":[{"name":"Oral Development and Orthodontics Unit of Oral Health Sciences, University of Oulu Oulu Finland"},{"name":"Medical Research Center, Oulu Oulu Finland"},{"name":"Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","unstructured":"KieserJ.Human adult odontometrics. 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