{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:21:57Z","timestamp":1760955717052},"reference-count":14,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T00:00:00Z","timestamp":1498176000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DE022032","R00DE022059"],"award-info":[{"award-number":["R01DE022032","R00DE022059"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10RR026645"],"award-info":[{"award-number":["S10RR026645"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Structured Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Correlating mechanical forces with quantifiable physical changes in the dentoalveolar complex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and Sample Population<\/jats:title><jats:p>Male 6\u2010week C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice (N=3), micro X\u2010ray\u2010computed tomography; post\u2010analysis software to extract physical changes in periodontal ligament (<jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content>)\u2010space.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Silicone\u2010elastic bands were placed between maxillary molars for 1\u00a0week, with the contralateral side as internal control. Average displacements between crowns and roots, and changes in <jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content>\u2010spaces were evaluated by registering X\u2010ray tomograms of experimental and control hemi\u2010maxillae. Histology illustrated mineral formation and resorption\u2010related events within narrowed and widened volumes of the <jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content>\u2010space.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>3D maps of changes in <jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content>\u2010space between molars illustrated coronal and root displacements of 640\u00a0\u03bcm and 180\u00a0\u03bcm, respectively, compared to 70\u00a0\u03bcm in controls. Orthodontic tooth movement (OTM) specimens exhibited an average net change of \u221220\u00a0\u03bcm in narrowed and +30\u00a0\u03bcm in widened <jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content>\u2010spaces. Bone and cementum were affected by the force on molars, and primary cementum was more affected than secondary cementum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This novel approach illustrates the importance of 3D\u2010imaging and analysing 3D alveolar socket subjected to <jats:styled-content style=\"fixed-case\">OTM<\/jats:styled-content> otherwise omitted by 2D micrographs.\u00a0A measured force on the crown elicits a response related to narrowed and widened regions in the 3D complex. <jats:styled-content style=\"fixed-case\">OTM<\/jats:styled-content> that exceeds <jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content>\u2010space can illicit biological responses that attempt to restore physiologic <jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content>\u2010space via remodelling of the periodontium. Regenerated weaker bone due to aseptic inflammation caused by orthodontics could leave patients at a higher risk of bone loss or root resorption if they later develop periodontitis, a form of septic inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12172","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T20:56:31Z","timestamp":1498251391000},"page":"100-105","source":"Crossref","is-referenced-by-count":11,"title":["Micro\u2010anatomical responses in periodontal complexes of mice to calibrated orthodontic forces on the crown"],"prefix":"10.1111","volume":"20","author":[{"given":"A.","family":"Pal","sequence":"first","affiliation":[{"name":"Departments of Preventive and Restorative Dental Sciences University of California San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Chen","sequence":"additional","affiliation":[{"name":"Departments of Preventive and Restorative Dental Sciences University of California San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Yang","sequence":"additional","affiliation":[{"name":"Departments of Preventive and Restorative Dental Sciences University of California San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Yang","sequence":"additional","affiliation":[{"name":"Departments of Preventive and Restorative Dental Sciences University of California San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Meng","sequence":"additional","affiliation":[{"name":"Orofacial Sciences School of Dentistry University of California San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. H.","family":"Jheon","sequence":"additional","affiliation":[{"name":"Orofacial Sciences School of Dentistry University of California San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. P.","family":"Ho","sequence":"additional","affiliation":[{"name":"Departments of Preventive and Restorative Dental Sciences University of California San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/2177-6709.20.6.068-074.oar"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345540330040701"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2005.10.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700509"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2015.04.002"},{"key":"e_1_2_8_7_1","first-page":"299","article-title":"Mechanobiology of the tooth movement during the orthodontic treatment: a literature review","volume":"65","author":"Isola G","year":"2016","journal-title":"Minerva Stomatol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/23.6.671"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2016.01.007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351897"},{"key":"e_1_2_8_11_1","volume-title":"Ten Cate's \u2010 Oral Histology: Development, Structure, and Function","author":"Cate T","year":"2013"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502693"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/2278-0203.119678"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4864195"},{"key":"e_1_2_8_15_1","volume-title":"A Fourier Transform Approach to Modeling Kinetics of Appositional Growth in Healthy vs. Diseased Mineralized Tissues","author":"Tam C","year":"2015"}],"container-title":["Orthodontics &amp; Craniofacial Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Focr.12172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ocr.12172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T18:37:34Z","timestamp":1694630254000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ocr.12172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":14,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/ocr.12172"],"URL":"https:\/\/doi.org\/10.1111\/ocr.12172","archive":["Portico"],"relation":{},"ISSN":["1601-6335","1601-6343"],"issn-type":[{"value":"1601-6335","type":"print"},{"value":"1601-6343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}