{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:55:38Z","timestamp":1762955738276},"reference-count":25,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T00:00:00Z","timestamp":1498176000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["K08 DE021705"],"award-info":[{"award-number":["K08 DE021705"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Orthodontic tooth movement (<jats:styled-content style=\"fixed-case\">OTM<\/jats:styled-content>) relies on the orchestration of clinical and biologic events that include the application of clinical force followed by a cascade of cellular and molecular responses. Our understanding about <jats:styled-content style=\"fixed-case\">OTM<\/jats:styled-content> today has evolved from, and is largely based on historic studies. However, the advances in bone biology and clinical orthodontics today continue to pave the pathway towards an improved knowledge base, and state of the art therapeutics in <jats:styled-content style=\"fixed-case\">OTM<\/jats:styled-content>. Osteoblasts and osteoclasts have been the primary cells analyzed in <jats:styled-content style=\"fixed-case\">OTM<\/jats:styled-content>. However, the role of osteocytes, a cell previously thought to be static, should be considered in light of new findings in molecular biological research. Osteocytes are now known to be significant in controlling responses to mechanical forces and therefore may be central to both <jats:styled-content style=\"fixed-case\">OTM<\/jats:styled-content> and normal tooth eruption. In this review, we explore the biology of <jats:styled-content style=\"fixed-case\">OTM<\/jats:styled-content> by focusing specifically on the potential role of osteocytes. Evidence from recent studies reveal that osteocytes have a role in controlling the response to mechanical forces and <jats:styled-content style=\"fixed-case\">OTM<\/jats:styled-content>. We therefore propose that these findings and further research endeavours may shape the future of clinical applications\u2014specifically enhanced outcomes in <jats:styled-content style=\"fixed-case\">OTM<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ocr.12176","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T20:56:31Z","timestamp":1498251391000},"page":"125-128","source":"Crossref","is-referenced-by-count":7,"title":["A new cyte in orthodontics: Osteocytes in tooth movement"],"prefix":"10.1111","volume":"20","author":[{"given":"E. E.","family":"Bumann","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Pediatric Dentistry University of Michigan School of Dentistry  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. A.","family":"Frazier\u2010Bowers","sequence":"additional","affiliation":[{"name":"Department of Orthodontics School of Dentistry University of North Carolina  Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,23]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"The Biology of Tooth Movement","author":"Norton LA","year":"1989"},{"key":"e_1_2_8_3_1","volume-title":"Orthodontics: Current Principles and Techniques","author":"Graber LW","year":"2012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2319\/110713-813.1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2012-1026"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513476037"},{"key":"e_1_2_8_7_1","first-page":"1","article-title":"Comparative behavior of human and animal tissue during experimental tooth movement","volume":"41","author":"Reitan K","year":"1971","journal-title":"Angle Orthod"},{"key":"e_1_2_8_8_1","volume-title":"Contemporary Orthodontics","author":"Proffit WR","year":"2013"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.05.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02279101"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1646"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034508330861"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2006.12.010"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.6.839"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509334649"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2822"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.9.5.7896017"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.03.007"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(81)90217-7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2013.03.015"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700509"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1980.tb00377.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120339"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513513588"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2009.10.021"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2439"}],"container-title":["Orthodontics &amp; Craniofacial Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Focr.12176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ocr.12176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T18:37:40Z","timestamp":1694630260000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ocr.12176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":25,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/ocr.12176"],"URL":"https:\/\/doi.org\/10.1111\/ocr.12176","archive":["Portico"],"relation":{},"ISSN":["1601-6335","1601-6343"],"issn-type":[{"value":"1601-6335","type":"print"},{"value":"1601-6343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}