{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:44:34Z","timestamp":1780479874203,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T00:00:00Z","timestamp":1500854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Structured Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Many reports suggest that children with cleft lip and palate (<jats:styled-content style=\"fixed-case\">CLP<\/jats:styled-content>) have delayed dental development and asymmetrical timing of tooth\u2010pair formation. We aimed to investigate the dental maturation of permanent teeth in children with complete unilateral <jats:styled-content style=\"fixed-case\">CLP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">UCLP<\/jats:styled-content>) and compare the findings with non\u2010<jats:styled-content style=\"fixed-case\">CLP<\/jats:styled-content> children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and sample population<\/jats:title><jats:p>This case\u2010control study used 115 radiographs of children with complete <jats:styled-content style=\"fixed-case\">UCLP<\/jats:styled-content> and controls (non\u2010<jats:styled-content style=\"fixed-case\">CLP<\/jats:styled-content> children matched on age, gender and ethnicity) from a hospital\u2010based dental clinic in Singapore.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Orthopantomographs of 60 children with complete <jats:styled-content style=\"fixed-case\">UCLP<\/jats:styled-content> (5\u20109\u00a0years old) and 55 children (9\u201013\u00a0years old) from the same cohort were investigated using the Demirjian's method and compared with controls to determine if there were any differences in dental maturation with age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Delayed dental maturation was found in the 5\u2010 to 9\u2010year\u2010old children with <jats:styled-content style=\"fixed-case\">UCLP<\/jats:styled-content> compared to controls by 0.55\u00a0years (standard deviation: 0.75) (<jats:italic>P<\/jats:italic>&lt;.001). There was no significant difference between the dental maturation of children with <jats:styled-content style=\"fixed-case\">UCLP<\/jats:styled-content> and controls in the 9\u2010 to 13\u2010year\u2010old group (<jats:italic>P<\/jats:italic>=.744). The group with <jats:styled-content style=\"fixed-case\">UCLP<\/jats:styled-content> had higher risk of asymmetrically developing tooth pairs than the control group for both age groups (<jats:italic>P<\/jats:italic>&lt;.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No difference in dental maturation between <jats:styled-content style=\"fixed-case\">UCLP<\/jats:styled-content> and controls in the 9\u2010 to 13\u2010year\u2010old group was found. However, there was diametrical difference in dental maturation in the 5\u2010 to 9\u2010year\u2010old group, which attenuated as they grew older. There was a consistently higher risk of asymmetrical tooth formation in children with <jats:styled-content style=\"fixed-case\">UCLP<\/jats:styled-content> than in controls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12196","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T11:12:37Z","timestamp":1500894757000},"page":"189-195","source":"Crossref","is-referenced-by-count":15,"title":["Longitudinal dental maturation of children with complete unilateral cleft lip and palate: A case\u2010control cohort study"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2528-667X","authenticated-orcid":false,"given":"E. L. Y.","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Orthodontics National Dental Centre  Singapore Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"Kuek","sequence":"additional","affiliation":[{"name":"Department of Orthodontics National Dental Centre  Singapore Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. C.","family":"Wong","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, Yong Loo Lin School of Medicine National University of Singapore, National University Health System  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Yow","sequence":"additional","affiliation":[{"name":"Department of Orthodontics National Dental Centre  Singapore Singapore City Singapore"},{"name":"Department of Dental Medicine Karolinska Institutet  Huddinge Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,24]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"311","article-title":"Incidence and epidemiology of cleft lip\/palate in Singapore","volume":"17","author":"Tan KL","year":"1988","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420460312"},{"key":"e_1_2_7_4_1","first-page":"58","article-title":"A comparative study of tooth formation in the permanent dentition of Finnish children with cleft lip and palate. 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